467250-76-6

Basic information

• Product Name: Oxazolo[2,3-a]isoindol-5(9bH)-one, 3-ethyl-2,3-dihydro-, (3R,9bS)- (9CI)
• Synonyms: Oxazolo[2,3-a]isoindol-5(9bH)-one, 3-ethyl-2,3-dihydro-, (3R,9bS)- (9CI)
• CAS NO: 467250-76-6
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.23712
• Product Categories: ETHYL
• Mol File: 467250-76-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Oxazolo[2,3-a]isoindol-5(9bH)-one, 3-ethyl-2,3-dihydro-, (3R,9bS)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazolo[2,3-a]isoindol-5(9bH)-one, 3-ethyl-2,3-dihydro-, (3R,9bS)- (9CI)(467250-76-6)
• EPA Substance Registry System: Oxazolo[2,3-a]isoindol-5(9bH)-one, 3-ethyl-2,3-dihydro-, (3R,9bS)- (9CI)(467250-76-6)

Safety Data

• Hazardous Substances Data: 467250-76-6(Hazardous Substances Data)

Upstream product

• 98289-79-3 1-iodo-2-phthalimidobutane 
• 85-44-9 phthalic anhydride 
• 66072-87-5 N-[1-(toluene-4-sulfonyloxymethyl)-propyl]-phthalimide 
• 169331-29-7 (1'R)-N-(2'-ethyl-1'-hydroxyethyl)-1H-isoindole-1,3(2H)-dione 
• 467250-79-9 (1'R,3RS)-2,3-dihydro-2-(2'-ethyl-1'-hydroxyethyl)-3-hydroxy-1H-isoindol-1-one 
• 42945-18-6 2-(1-hydroxybutan-2-yl)isoindoline-1,3-dione 

Relevant articles and documents

Diastereoselective access to chiral non-racemic [1,3]oxazolo-[2,3-a] isoindol-5-one ring systems via o-cationic cyclization

The title compounds 4 have been prepared from suitable β-amino-alcohol 2 and phthalic anhydride (5) in a three-step sequence in moderate to good yields (58-94%). The key step of this methodology is based on an intramolecular O-cationic cyclization involving N-acyliminium species. The high levels of the observed chemoselectivity during the intermolecular or intramolecular cyclization were also discussed.

Synthesis of (R)- and (S)-2-Aminobutane from (S)- and (R)-2-Aminobutanol

(R)-(-)- and (S)-(+)-2-Aminobutane (1) can be synthesized in good yield and high optical purity from (S)-(+)- and (R)-(-)-2-aminobutanol (2) respectively.