467442-07-5

Basic information

• Product Name: 4-BROMOMETHYL-3-CHLOROBENZOIC ACID
• Synonyms: 4-BROMOMETHYL-3-CHLOROBENZOIC ACID
• CAS NO: 467442-07-5
• Molecular Formula: C₈H₆BrClO₂
• Molecular Weight: 249.49
• Mol File: 467442-07-5.mol

Chemical Properties

• Boiling Point: 352℃
• Flash Point: 167℃
• Appearance: /
• Density: 1.739
• PKA: 3.73±0.10(Predicted)
• CAS DataBase Reference: 4-BROMOMETHYL-3-CHLOROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOMETHYL-3-CHLOROBENZOIC ACID(467442-07-5)
• EPA Substance Registry System: 4-BROMOMETHYL-3-CHLOROBENZOIC ACID(467442-07-5)

Safety Data

• Hazardous Substances Data: 467442-07-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMOMETHYL-3-CHLOROBENZOIC ACID is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-BROMOMETHYL-3-CHLOROBENZOIC ACID serves as an intermediate in the production of pesticides. Its chemical properties enable the creation of effective pest control agents, enhancing crop protection and contributing to agricultural productivity.
Used in Dye and Pigment Production:
4-BROMOMETHYL-3-CHLOROBENZOIC ACID is utilized as a raw material in the manufacturing of dyes and pigments. Its chemical composition contributes to the development of a wide range of colorants used in various industries, including textiles, plastics, and printing inks.
Used in Organic Compound Synthesis:
4-BROMOMETHYL-3-CHLOROBENZOIC ACID is also employed in the synthesis of other organic compounds, broadening its applications across different chemical and industrial processes. Its versatility in chemical reactions makes it a valuable component in the creation of diverse organic products.

Upstream product

• 5162-82-3 3-chloro-4-methylbenzoic acid 
• 21924-83-4 4-(bromomethyl)-3-chlorobenzonitrile 

Downstream Products

• 865449-91-8 3-chloro-4-{4-[(7-fluoro-4-oxo-4H-chromene-2-carbonyl)-amino]-piperidin-1-ylmethyl}-benzoic acid 
• 1033951-14-2 4-{4-[5-Bromo-4-(4-cyano-2,6-dimethyl-phenoxy)-pyrimidin-2-ylamino]-piperidin-1-ylmethyl}-3-chloro-benzoic acid 

Relevant articles and documents

QUINOLINES AND THEIR THERAPEUTIC USE

Compounds of formula [1] are CRTH2 antagonists, useful in the treatment of conditions having an inflammatory component; in which: R1, R2, R3, R4 and R5 are independently hydrogen, C1-C6alkyl, C1- C6fluoroalkyl, cyclopropyl, halo, -S(O)nR6, -SO2NR7R8, -NR7R8, -NR7C(O)R6, -CO2R7, -C(O)NR7R8, -C(O)R6, -NO2, -CN or a group -OR9; wherein each R6 is independently C1-C6alkyl, C1-C6fluoroalkyl, cycloalkyl, aryl, or heteroaryl; R7, R8 are independently C1-C6alkyl, C1-C6fluoroalkyl, cycloalkyl, cycloalkyl-(C1-C6alkyl)-, aryl, heteroaryl or hydrogen; R9 is hydrogen, C1-C6alkyl, C1-C6fluoroalkyl, cycloalkyl, cylcoalkyl-(C1-C6alkyl)-, or a group -SO2R6; A is -CHR10-, -C(O)-, -S(O)n-, -0-, or -NR10- wherein n is an integer from 0-2 and R10 is hydrogen, C1-C3alkyl, or C1-C6fluoroalkyl group; B is a direct bond, or a divalent radical selected from -CH2-, -CH2CH2-, -CHR11-, -CR11R12-, -CH2CHR11-, -CH2CR11R12-, -CHR11CHR12-, and divalent radicals of formula -(CR11R12)P-Z- wherein Z is attached to the ring carrying R1, R2 and R3; wherein R11 is C1-C3alkyl, cyclopropyl, C1-C6fluoroalkyl; R12 is methyl or fluoromethyl; p is independently 1 or 2; and Z is -0-, -NH-, or -S(O)n-, wherein n is an integer from 0-2; X is a carboxylic acid, tetrazole, 3-hydroxyisoxazole, hydroxamic acid, phosphinate, phosphonate, phosphonamide, or sulfonic acid group, or a group of formula C(=O)NHSO2R6or SO2NHC(=O)R6; and Y is aryl, heteroaryl, aryl-fused- heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl group.

Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity

A series of potent 2-carboxychromone-based melanin-concentrating hormone receptor 1 (MCHr1) antagonists were synthesized and evaluated for hERG (human Ether-a-go-go Related Gene) channel affinity and functional blockade. Basic dialkylamine-terminated anal

Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor

The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.