467461-40-1

Basic information

• Product Name: 6-(METHYLSULFONYL)-1H-INDOLE
• Synonyms: 1H-Indole,6-(Methylsulfonyl)-;1H-Indol-6-yl methyl sulphone
• CAS NO: 467461-40-1
• Molecular Formula: C9H9NO2S
• Molecular Weight: 195.24
• Mol File: 467461-40-1.mol

Chemical Properties

• Melting Point: 151℃
• Appearance: /
• CAS DataBase Reference: 6-(METHYLSULFONYL)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(METHYLSULFONYL)-1H-INDOLE(467461-40-1)
• EPA Substance Registry System: 6-(METHYLSULFONYL)-1H-INDOLE(467461-40-1)

Safety Data

• Hazardous Substances Data: 467461-40-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-(METHYLSULFONYL)-1H-INDOLE is used as a building block for the synthesis of various pharmaceuticals due to its potential therapeutic effects in treating diseases such as cancer, inflammation, and neurological disorders. Its incorporation into drug molecules can enhance their efficacy and selectivity.
Used in Agrochemical Industry:
6-(METHYLSULFONYL)-1H-INDOLE is utilized as a component in the development of agrochemicals, contributing to the creation of more effective and targeted pesticides or herbicides.
Used in Antioxidant Applications:
6-(METHYLSULFONYL)-1H-INDOLE is employed for its antioxidant properties, which can help in the development of products that protect against oxidative stress and related cellular damage.
Used in Antimicrobial Applications:
6-(METHYLSULFONYL)-1H-INDOLE is used for its antimicrobial properties, making it a potential candidate for the development of new antimicrobial agents to combat resistant strains of bacteria and other pathogens.
Used in Research and Development:
6-(METHYLSULFONYL)-1H-INDOLE is used as a subject of study in research for its potential applications in medicinal chemistry, biochemistry, and drug development, aiding in the discovery of new therapeutic agents and understanding of disease mechanisms.

Upstream product

• 52415-29-9 6-bromo-1H-indole 
• 20277-69-4 sodium methansulfinate 

Downstream Products

• 1068969-93-6 2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid (6-methanesulfonyl-indol-1-yl)-amide 
• 927427-56-3 6-methylsulfonyl-2,3-dihydro-1H-indole 

Relevant articles and documents

INHIBITORS OF CYCLIN DEPENDNT KINASE 7 (CDK7)

The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Catalytic synthesis method of indole compounds

The invention discloses a catalytic synthesis method of indole compounds.The method includes the following steps of firstly, conducting stirring reaction on ortho-nitrostyrolene or derivatives of ortho-nitrostyrolene, bis(pinacolato)diboron, alkali and low-grade saturated monohydric alcohol under the atmosphere of nitrogen; secondly, cooling the reaction product in the first step to the room temperature, adding ethyl acetate to be sufficiently mixed, and washing with ethyl acetate after filtering; thirdly, spin-drying low-grade saturated monohydric alcohol in an organic phase of the material obtained in the second step, passing through a silica gel column, and drip washing the silica gel column with eluent composed of petroleum ether and ethyl acetate to obtain pure products, namely, the indole compounds.By means of the method, under the neutral conditions, bis(pinacolato)diboron low in price serves as the raw material, friendly low-grade saturated monohydric alcohol serves as the solvent, the indole compounds are obtained through simple operation, the raw materials are low in price and easy to obtain, efficiency and safety are high, and wide expandability and good industrial application prospects are achieved.