Regioselective synthesis of substituted imidate N-[1- methyleneisobenzofuran-3(1H)-ylidene]benzenamines via palladium-catalyzed tandem heteroannulation of o-(1-alkynyl)benzamides with iodobenzene
A variety of substituted imidate N-[1-methyleneisobenzofuran-3(1H)-ylidene] benzenamines have been prepared in good to excellent yields by the palladium-catalyzed tandem heteroannulation of o-(1-alkynyl)benzamides with iodobenzene. The products obtained from this process were unusual substituted N-[isobenzofuran-3(1H)-ylidene]benzenamines. The tandem cyclization of readily available o-(1-alkynyl)benzamides and aryl iodides provided a powerful tool for the preparation of functionally substituted N-[isobenzofuran-3(1H)-ylidene] benzenamine compounds. Georg Thieme Verlag Stuttgart New York.
Preparation method of 3-methylene isoindole-1-one derivatives
The invention relates to a preparation method of 3-methylene isoindole-1-one derivatives. The preparation method comprises the following steps: an N-substituted 2-chlorobenzamide derivative in formula (1), alkyne-terminated compounds in formula (2) and ni