BIVALENT LECA INHIBITORS TARGETING BIOFILM FORMATION OF PSEUDOMONAS AERUGINOSA
The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.
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(2021/05/15)
NOVEL CURING AGENTS AND DEGRADABLE POLYMERS AND COMPOSITES BASED THEREON
The present invention provides,among others,compounds of Formula (I)or a salt thereof,methods for making these compounds,degradable polymers and reinforced composites made therefrom,and methods for degrading and/or recycling the degradable polymers and re
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(2014/11/11)
Novel di- and polyamino compounds for use in the preparation of polyurethanes
Bis(aminophenoxy)methanes of formula (I), alkyl-substituted derivatives thereof and modified DADPM derived thereof; and conversion of these compounds into polyols and into polyisocyanates, which in turn can be used in the preparation of polyurethanes.
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(2008/06/13)
Novel Bis as Antitrypanosomal Agents
A series of novel 1,1'-(4,1-phenylene)bis was prepared and evaluated for activity against Trypanosoma rhodesiense in mice.The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed.The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends encouragement to further development of this structural class.
Turner, William R.,Werbel, Leslie M.
p. 1728 - 1740
(2007/10/02)
Poly(6-oxy-2,2,4-trialkyl-1,2-dihydroquinoline)alkylene compounds as antidegradants for rubber
Vulcanizable or vulcanized diene elastomers containing stabilizing amounts of certain poly(6-oxy-2,2,4-trialkyl-1,2-dihydroquinoline)alkylene antidegradants show resistance to ozone attack. The antidegradants themselves are novel compounds.
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(2008/06/13)
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