A domino annulation reaction under Willgerodt-Kindler conditions
(Chemical Equation Presented) Butanone side chains at arenes and hetarenes, efficiently introduced by a Heck-type reaction, are transformed to annulated thieno[3,2-b]thiophenes in a domino redox process under Willgerodt-Kindler conditions. A nucleophilic aromatic substitution with an intermediary thioenolate is a reasonable key step of this process.
POTENTIAL ANTIDEPRESSANT AND ANTI-INFLAMMATORY AGENTS: 4-(2-PROPYLTHIO)ACETOPHENONE OXIMES AND 4-(2-PROPYLTHIO)PHENYLALKANOIC ACIDS
4-(2-Propylthio)acetophenone oxime (IV) was reacted with 2-aminoethyl chloride and 3-dimethylaminopropyl chloride to give the O-(aminoalkyl)oximes V and VI which are analogues of the antidepressant agent fluvoxamine (I).Kindler-Willgerodt reaction of 4-(2