471938-43-9

Basic information

• Product Name: 1H-Indole,6-isothiocyanato-(9CI)
• Synonyms: 1H-Indole,6-isothiocyanato-(9CI)
• CAS NO: 471938-43-9
• Molecular Formula: C₉H₆N₂S
• Molecular Weight: 174.226
• Product Categories: INDOLE
• Mol File: 471938-43-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole,6-isothiocyanato-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole,6-isothiocyanato-(9CI)(471938-43-9)
• EPA Substance Registry System: 1H-Indole,6-isothiocyanato-(9CI)(471938-43-9)

Safety Data

• Hazardous Substances Data: 471938-43-9(Hazardous Substances Data)

Usage

Structure

A derivative of indole with an isothiocyanate functional group attached at the 6-position

Usage

Commonly used in organic synthesis and medicinal chemistry for the preparation of various indole-based compounds

Biological activities

Potential anti-inflammatory, anti-cancer, and antimicrobial properties

Reactivity

The isothiocyanate group can react with biological nucleophiles, contributing to the compound's biological effects

Versatility

Has potential applications in both chemical and biological research.

Upstream product

• 5318-27-4 6-amino-1H-indole 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 463-71-8 thiophosgene 

Relevant articles and documents

SMALL MOLECULE STING ANTAGONISTS

The present invention relates to compounds of formula (I). The compounds maybe used to antagonise the Stimulator of Interferon Genes (STING) protein and may thereby treat liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis (NASH), pulmonary fibrosis, lupus, sepsis, rheumatoid arthritis (RA), type I diabetes, STING- associated vasculopathy with onset in infancy (SAVI), Aicardi-Goutieres syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), retinal vasculopathy, neuroinflammation, systemic inflammatory response syndrome, pancreatitis, cardiovascular disease, renal fibrosis, stroke and age-related macular degeneration (AMD).

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.