- Enantioselectivity in the Biotransformation of Mono- and Bicyclic Monoterpenoids with the Cultured Cells of Nicotiana tabacum
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The biotransformation of the enantiomeric pairs of p-menthane and bicyclo and heptane derivatives with the cultured cells of Nicotiana tabacum was investigated.It was found that (i) the cultured cells discriminate the enantiomers of p-menthan-2-ol and bicycloheptan-2-ol and bicycloheptan-3-ol derivatives, and enantioselectively convert these alcohols to the corresponding ketones, (ii) the cells reduce the carbonyl group of p-methan-2-one derivatives to a high extent, but not that of p-menthan-3-ones, and (iii) the cells discriminate the enantiomers of bicyclohept-2-en-4-one (verbenone) and enantioselectively reduce the C-C double bond of the (1S,5S)-enantiomer.
- Hamada, Hiroki
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