- Synthesis of unsaturated 1,4-heteroatom-containing benzo-fused heterocycles using a sequential isomerization-ring-closing metathesis strategy
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A small library of 1,4-benzodioxins and 4H-1,4-benzoxazines was synthesized from the corresponding bis-allyloxy precursors by way of an initial isomerization to the bis-vinyloxy compounds, followed by a ring-closing metathesis using the second generation Grubbs' catalyst (G2). A related strategy, starting from benzene-1,2-dithiol and 2-mercaptophenol, afforded benzodithiin and 1,4-benzoxathiin, respectively.
- Morgans, Garreth L.,Ngidi, E. Lindani,Madeley, Lee G.,Khanye, Setshaba D.,Michael, Joseph P.,de Koning, Charles B.,van Otterlo, Willem A.L.
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experimental part
p. 10650 - 10659
(2010/01/16)
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- Isomerization and ring-closing metathesis for the synthesis of 6-, 7- and 8-membered benzo- and pyrido-fused N,N-, N,O- and N,S-heterocycles
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An isomerization-ring-closing metathesis (RCM) strategy afforded N-substituted 4H-1,4-benzoxazines from the protected N-allyl-2-(allyloxy) anilines. In addition, RCM was used to synthesize the N-substituted, 8-membered benzo-fused heterocycles from the re
- Van Otterlo, Willem A.L.,Morgans, Garreth L.,Khanye, Setshaba D.,Aderibigbe, Blessing A.A.,Michael, Joseph P.,Billing, David G.
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p. 9171 - 9175
(2007/10/03)
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- Efficient atom economic approaches towards macrocyclic crownamides via ring closure metathesis
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RCM of suitable 1,ω-dienes led to efficient atom economic synthetic approaches towards azacrown ether derivatives with eight- to twenty four-membered ring sizes.
- Ibrahim, Yehia A,Behbehani, Haider,Ibrahim, Maher R
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p. 4207 - 4210
(2007/10/03)
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