47367-75-9

Basic information

• Product Name: oxazine 1
• Synonyms: N,N,N',N'-Tetraethyloxoninecation; Oxazine 1
• CAS NO: 47367-75-9
• Molecular Formula: C₂₀H₂₆N₃O
• Molecular Weight: 324.43994
• EINECS: 264-355-5
• Mol File: 47367-75-9.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: oxazine 1(CAS DataBase Reference)
• NIST Chemistry Reference: oxazine 1(47367-75-9)
• EPA Substance Registry System: oxazine 1(47367-75-9)

Safety Data

• Hazardous Substances Data: 47367-75-9(Hazardous Substances Data)

Usage

InChI:InChI=1/2C20H26N3O.4ClH.Zn/c2*1-5-22(6-2)15-9-11-17-19(13-15)24-20-14-16(23(7-3)8-4)10-12-18(20)21-17;;;;;/h2*9-14H,5-8H2,1-4H3;4*1H;/q2*+1;;;;;+2/p-4/r2C20H26N3O.Cl4Zn/c2*1-5-22(6-2)15-9-11-17-19(13-15)24-20-14-16(23(7-3)8-4)10-12-18(20)21-17;1-5(2,3)4/h2*9-14H,5-8H2,1-4H3;/q2*+1;-2

Upstream product

• 53342-54-4 leucooxazine 725 
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• 83531-24-2 3,7-bis(diethylamino)-10H-phenoxazine-10-carbonyl chloride 
• 877669-21-1 3,7-bis-diethylamino-phenoxazine-10-carbothioic acid S-naphthalen-1-yl ester 
• 877669-19-7 3,7-bis-diethylamino-phenoxazine-10-carbothioic acid S-p-tolyl ester 
• 877669-17-5 3,7-bis(N,N-diethylamino)-10-(phenylthio)carbonylphenoxazine 
• 877669-22-2 3,7-bis-diethylamino-phenoxazine-10-carbothioic acid S-tert-butyl ester 

Relevant articles and documents

Phenoxazine-based Near-infrared Fluorescent Probes for the Specific Detection of Copper (II) Ions in Living Cells

Abstract: It is well known that copper ions play a critical role in various physiological processes. However, a variety of human diseases are tightly correlated with copper overload. Although there are numerous fluorescent probes capable of detecting copper ions, most of them are “turn-off” probes owing to copper (II) ions fluorescence quenching effect, resulting in poor sensitivity. Herein, a novel “turn-on” near-infrared (NIR) fluorescent probe PZ-N based on phenoxazine was designed and synthesized for the selective detection of copper (II) ions (Cu2+). Upon the addition of Cu2+, the probe could quickly react with Cu2+ and emit strong fluorescence, along with colour change from colourless to obvious blue. Moreover, the probe PZ-N showed good water solubility, high selectivity, and excellent sensitivity with low limit of detection (1.93 nM) towards copper (II) ions. More importantly, PZ-N was capable of effectively detecting Cu2+ in living cells.

The near-infrared fluorescent probes based on phenoxazine for the rapid detection of hypochlorous acid

Hypochlorous acid (HOCl) is tightly related with a series of diseases, and plays an important part in biological processes. Herein, we designed and synthesized two “turn-on” near-infrared (NIR) probes (BC-2 and BC-3) based on phenoxazine to sense and imag

Synthesis and radiation sensitivity of phenoxazine type color formers including thiol ester protective group

3,7-Bis(N,N-diethylamino)-10-(phenylthio)carbonylphenoxazine (1a) and its analogs (1b-f) were synthesized and the color change after γ irradiation was investigated. The color change of acetonitrile solutions of 1a ([1a] 0 = 1.0 × 10-3 M) after γ irradiation was identified by naked eyes at the dose of 20 Gy. Phenylthio-substituted compound la showed more significant absorbance increase than phenoxy-substituted compound, 3,7-bis(N,N-diethylamino)-10-phenoxycarbonylphenoxazine (2a). The C-S cleavage in la by γ irradiation was revealed to occur more easily than the C-O cleavage in 2a. The sensitivity of the color formers 1a-f) to γ rays was correlated with the stability of the thiyl radicals generated in the reaction.