A mild, efficient method for the synthesis of aromatic and aliphatic sulfonamides
A two-step method was developed for the synthesis of aromatic and aliphatic sulfonamides from the corresponding sulfinates using bis(2,2,2-trichloroethyl)azodicarboxylate as the electrophilic nitrogen source. The intermediate sulfonylhydrazides were obtained in very good yields and were cleaved under reductive conditions to deliver the desired sulfonamides. A variety of substituents in the aromatic ring are well tolerated as well as heterocycles.
Chan, Wing Yan,Berthelette, Carl
p. 4537 - 4540
(2007/10/03)
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