474706-34-8

Basic information

• Product Name: 3-[4-(Methylthio)phenyl]-1H-pyrazole
• Synonyms: 3-[4-(Methylthio)phenyl]-1H-pyrazole;3-(4-methylsulfanylphenyl)-2H-pyrazole;3-[4-(methylthio)phenyl]-2H-pyrazole
• CAS NO: 474706-34-8
• Molecular Formula: C₁₀H₁₀N₂S
• Molecular Weight: 190.2648
• Mol File: 474706-34-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[4-(Methylthio)phenyl]-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(Methylthio)phenyl]-1H-pyrazole(474706-34-8)
• EPA Substance Registry System: 3-[4-(Methylthio)phenyl]-1H-pyrazole(474706-34-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 474706-34-8(Hazardous Substances Data)

Usage

Main properties

Chemical compound

Specific content

Also known as 4-(methylthio)phenyl-1H-pyrazol-3-amine
Contains a methylthio group on the phenyl ring
Used in synthesis of pharmaceuticals and agrochemicals
Potential building block for biologically active molecules and drugs

Upstream product

• 98546-51-1 (4-thiomethoxyphenyl)boronic acid 
• 14521-80-3 3-bromo-1H-pyrazole 
• 1778-09-2 4-(Methylthio)acetophenone 

Downstream Products

• 474706-37-1 4-Bromo-3-[4-(methylsulfanyl)phenyl)-1H-pyrazole 

Relevant articles and documents

Suzuki-miyaura cross-coupling of unprotected, nitrogen-rich heterocycles: Substrate scope and mechanistic investigation

The Suzuki-Miyaura cross-coupling of unprotected, nitrogen-rich heterocycles using precatalysts P1 or P2 is reported. The procedure allows for the reaction of variously substituted indazole, benzimidazole, pyrazole, indole, oxindole, and azaindole halides under mild conditions in good to excellent yields. Additionally, the mechanism behind the inhibitory effect of unprotected azoles on Pd-catalyzed cross-coupling reactions is described based on evidence gained through experimental, crystallographic, and theoretical investigations.

NITROGENOUS FUSED?RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF

The present invention provides a compound having an excellent inhibitory action on activation of STAT6 and a pharmaceutical composition thereof. Inparticular, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, X represents a nitrogen-containing condensed aromatic heterocyclic group such as imidazo[1,2-a]pyridine, benzimidazole, quinazoline, quinoline, or 2,1-benzisoxazole and has (R4)n as substituent groups; Y represents a C3-8 cycloalkyl group, C4-8 cycloalkenyl group, 5- to 14-membered non-aromatic heterocyclic group, C6-14 aromatic hydrocarbon cyclic group or 5- to 14-membered aromatic heterocyclic group; n in (R4)n is 0, 1, 2 or 3, and Z groups independently represent (1) hydrogen atom, (2) amino group, (3) halogen atom, (4) hydroxyl group, (5) nitro group, (6) cyano group, (7) azido group, (8) formyl group, (9) hydroxyamino group, (10) sulfamoyl group, (11) guanodino group, (12) oxo group, (13) C2-6 alkenyl group, (14) C1-6 alkoxy group, (15) C1-6 alkylhydroxyamino group, (16) halogenated C1-6 alkyl group, (17) halogenated C2-6 alkenyl group, (18) (i) C3-7cycloalkyl group, (ii) C3-7cycloalkenyl group, (iii) 5- to 14-membered non-aromatic heterocyclic group, each of which may have one or more substituent groups Q, or (19) formula -M1-M2-M3, R1 represents (1) hydrogen atom, (2) halogen atom, (3) hydroxyl group, (4) nitro group, (5) cyano group, (6) halogenated C1-6 alkyl group, (7) C2-6 alkyl group substituted with a hydroxyl or cyano group, (8) C2-6 alkenyl group, or (9) formula -L1-L2-L3, and R2 represents a hydrogen atom or a protecting group; and R3 represents a hydrogen atom, halogen atom, cyano group, amino group, C1-4 alkyl group or halogenated C1-4 alkyl group.