474708-88-8

Basic information

• Product Name: 6-bromo-8-chloroimidazo[1,2-a]pyridine
• Synonyms: 6-bromo-8-chloroimidazo[1,2-a]pyridine;IMidazo[1,2-a]pyridine, 6-broMo-8-chloro-
• CAS NO: 474708-88-8
• Molecular Formula: C₇H₄BrClN₂
• Molecular Weight: 231.4771
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyridine series
• Mol File: 474708-88-8.mol

Chemical Properties

• Melting Point: 133 °C
• Appearance: /
• Density: 1.845 g/cm³
• Refractive Index: 1.707
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.29±0.50(Predicted)
• CAS DataBase Reference: 6-bromo-8-chloroimidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-8-chloroimidazo[1,2-a]pyridine(474708-88-8)
• EPA Substance Registry System: 6-bromo-8-chloroimidazo[1,2-a]pyridine(474708-88-8)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 474708-88-8(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
6-bromo-8-chloroimidazo[1,2-a]pyridine is used as a research compound for the investigation of its chemical properties and potential applications in the field of chemistry. Its unique structure with two different halogen atoms may offer insights into the behavior of organoheterocyclic compounds and their interactions with other molecules.
Used in Synthesis:
6-bromo-8-chloroimidazo[1,2-a]pyridine is used as a synthetic intermediate in the preparation of more complex molecules. Its imidazopyridine core structure and halogenated nature may be exploited in the synthesis of pharmaceuticals, agrochemicals, or other specialty chemicals that require such structural features.
Used in Drug Discovery:
Although the information on its uses is limited, 6-bromo-8-chloroimidazo[1,2-a]pyridine may be used as a starting material in drug discovery programs. Its potential as a lead compound or a building block for the development of new therapeutic agents could be explored, given its unique structural features and the possibility of further functionalization.
Used in Material Science:
6-bromo-8-chloroimidazo[1,2-a]pyridine may also find applications in material science, particularly in the development of new materials with specific properties. Its organoheterocyclic nature and the presence of halogens could contribute to the creation of materials with tailored electronic, optical, or mechanical properties for various applications.

InChI:InChI=1/C7H4BrClN2/c8-5-3-6(9)7-10-1-2-11(7)4-5/h1-4H

Upstream product

• 474708-87-7 6-bromo-8-chloro-2,3-dihydroimidazo[1,2-a]pyridine 

Downstream Products

• 474708-91-3 8-Chloro-6-(1-trityl-1H-4-pyrazolyl]imidazo[1,2-a]pyridine 
• 474709-13-2 8-Chloro-6-[3-(2,4-difluorophenyl)-1-trityl-1H-4-pyrazolyl]imidazo[1,2-a]pyridine 

Relevant articles and documents

IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF

The invention provides compounds of formula (1), stereoisomers and tautomers thereof, or pharmaceutically acceptable salts, solvates and polymorphs thereof, and processes for their preparation. The invention further relates to pharmaceutical compositions containing said compounds and their use in the treatment of diseases or disorders mediated by one or more proinflammatory cytokines selected from TNF-a, IL-Ιβ, IL-6, IL-8, IL-12, IL-17 or IL-23.

NITROGENOUS FUSED?RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF

The present invention provides a compound having an excellent inhibitory action on activation of STAT6 and a pharmaceutical composition thereof. Inparticular, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, X represents a nitrogen-containing condensed aromatic heterocyclic group such as imidazo[1,2-a]pyridine, benzimidazole, quinazoline, quinoline, or 2,1-benzisoxazole and has (R4)n as substituent groups; Y represents a C3-8 cycloalkyl group, C4-8 cycloalkenyl group, 5- to 14-membered non-aromatic heterocyclic group, C6-14 aromatic hydrocarbon cyclic group or 5- to 14-membered aromatic heterocyclic group; n in (R4)n is 0, 1, 2 or 3, and Z groups independently represent (1) hydrogen atom, (2) amino group, (3) halogen atom, (4) hydroxyl group, (5) nitro group, (6) cyano group, (7) azido group, (8) formyl group, (9) hydroxyamino group, (10) sulfamoyl group, (11) guanodino group, (12) oxo group, (13) C2-6 alkenyl group, (14) C1-6 alkoxy group, (15) C1-6 alkylhydroxyamino group, (16) halogenated C1-6 alkyl group, (17) halogenated C2-6 alkenyl group, (18) (i) C3-7cycloalkyl group, (ii) C3-7cycloalkenyl group, (iii) 5- to 14-membered non-aromatic heterocyclic group, each of which may have one or more substituent groups Q, or (19) formula -M1-M2-M3, R1 represents (1) hydrogen atom, (2) halogen atom, (3) hydroxyl group, (4) nitro group, (5) cyano group, (6) halogenated C1-6 alkyl group, (7) C2-6 alkyl group substituted with a hydroxyl or cyano group, (8) C2-6 alkenyl group, or (9) formula -L1-L2-L3, and R2 represents a hydrogen atom or a protecting group; and R3 represents a hydrogen atom, halogen atom, cyano group, amino group, C1-4 alkyl group or halogenated C1-4 alkyl group.