474709-84-7

Basic information

• Product Name: 1-(3-CHLORO-PHENYL)-CYCLOPROPYLAMINE
• Synonyms: 1-(3-CHLOROPHENYL)CYCLOPROPANAMINE;1-(3-CHLORO-PHENYL)-CYCLOPROPYLAMINE;Cyclopropanamine, 1-(3-chlorophenyl)-;1-(3-chlorophenyl)cyclopropanamine(SALTDATA: HCl);1-(3-Chlorophenyl)cyclopropan-1-amine
• CAS NO: 474709-84-7
• Molecular Formula: C₉H₁₀ClN
• Molecular Weight: 167.6354
• Mol File: 474709-84-7.mol

Chemical Properties

• Boiling Point: 255.349°C at 760 mmHg
• Flash Point: 108.232°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1-(3-CHLORO-PHENYL)-CYCLOPROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLORO-PHENYL)-CYCLOPROPYLAMINE(474709-84-7)
• EPA Substance Registry System: 1-(3-CHLORO-PHENYL)-CYCLOPROPYLAMINE(474709-84-7)

Safety Data

• Hazardous Substances Data: 474709-84-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Chloro-phenyl)-cyclopropylamine is used as a key building block for the synthesis of a variety of drugs and biologically active compounds. Its unique structure allows it to be a versatile component in the creation of new pharmaceuticals.
Used in Research and Development:
In the realm of research and development, 1-(3-Chloro-phenyl)-cyclopropylamine is utilized for exploring its potential therapeutic applications. It holds promise, particularly in the treatment of psychiatric disorders and central nervous system-related conditions, due to its ability to interact with specific biological targets.
Safety Considerations:
Given its classification as a hazardous substance, 1-(3-Chloro-phenyl)-cyclopropylamine must be handled with care. Proper safety protocols and equipment are essential to minimize risks associated with its use, ensuring the safety of both individuals and the environment.

InChI:InChI=1/C9H10ClN/c10-8-3-1-2-7(6-8)9(11)4-5-9/h1-3,6H,4-5,11H2

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 925-90-6 ethylmagnesium bromide 
• 2386-64-3 ethylmagnesium chloride 
• 1529-41-5 3-chloro-benzeneacetonitrile 

Downstream Products

• 474699-20-2 N₁-[1-(3-chlorophenyl)cyclopropyl]-2-fluoro-4-[6-(1-trityl-1H-4-pyrazolyl)imidazo[1,2-a]pyridin-3-yl]benzamide 

Relevant articles and documents

NOVEL POTASSIUM CHANNEL INHIBITORS

The present invention relates to novel compounds, pharmaceutical compositions comprising such compounds and their use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.

INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD)

The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

NITROGENOUS FUSED?RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF

The present invention provides a compound having an excellent inhibitory action on activation of STAT6 and a pharmaceutical composition thereof. Inparticular, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, X represents a nitrogen-containing condensed aromatic heterocyclic group such as imidazo[1,2-a]pyridine, benzimidazole, quinazoline, quinoline, or 2,1-benzisoxazole and has (R4)n as substituent groups; Y represents a C3-8 cycloalkyl group, C4-8 cycloalkenyl group, 5- to 14-membered non-aromatic heterocyclic group, C6-14 aromatic hydrocarbon cyclic group or 5- to 14-membered aromatic heterocyclic group; n in (R4)n is 0, 1, 2 or 3, and Z groups independently represent (1) hydrogen atom, (2) amino group, (3) halogen atom, (4) hydroxyl group, (5) nitro group, (6) cyano group, (7) azido group, (8) formyl group, (9) hydroxyamino group, (10) sulfamoyl group, (11) guanodino group, (12) oxo group, (13) C2-6 alkenyl group, (14) C1-6 alkoxy group, (15) C1-6 alkylhydroxyamino group, (16) halogenated C1-6 alkyl group, (17) halogenated C2-6 alkenyl group, (18) (i) C3-7cycloalkyl group, (ii) C3-7cycloalkenyl group, (iii) 5- to 14-membered non-aromatic heterocyclic group, each of which may have one or more substituent groups Q, or (19) formula -M1-M2-M3, R1 represents (1) hydrogen atom, (2) halogen atom, (3) hydroxyl group, (4) nitro group, (5) cyano group, (6) halogenated C1-6 alkyl group, (7) C2-6 alkyl group substituted with a hydroxyl or cyano group, (8) C2-6 alkenyl group, or (9) formula -L1-L2-L3, and R2 represents a hydrogen atom or a protecting group; and R3 represents a hydrogen atom, halogen atom, cyano group, amino group, C1-4 alkyl group or halogenated C1-4 alkyl group.

A direct synthesis of 1-aryl- and 1-alkenylcyclopropylamines from aryl and alkenyl nitriles

The reaction of various aromatic nitriles with 1.1 equiv of Ti(Oi-Pr)4 and 2.2 equiv of EtMgBr followed by addition of a Lewis acid gave 1-aryl cyclopropylamines in 43-76% yields. Under similar conditions, conjugated alkene-nitriles afford 1-alkenylcyclopropylamines (42-65%).