474759-76-7

Basic information

• Product Name: 2-(4-TRIFLUOROMETHOXYBENZYLIDENE)-MALONONITRILE
• Synonyms: 4-(TRIFLUOROMETHOXY)BENZYLEDENEMALONITRILE;4-(TRIFLUOROMETHOXY)BENZALMALONONITRILE;2-(TRIFLUOROMETHOXY)BENZALMALONITRILE;2-(4-TRIFLUOROMETHOXYBENZYLIDENE)-MALONONITRILE;RARECHEM AL BX 0284
• CAS NO: 474759-76-7
• Molecular Formula: C₁₁H₅F₃N₂O
• Molecular Weight: 238.17
• Mol File: 474759-76-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-TRIFLUOROMETHOXYBENZYLIDENE)-MALONONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-TRIFLUOROMETHOXYBENZYLIDENE)-MALONONITRILE(474759-76-7)
• EPA Substance Registry System: 2-(4-TRIFLUOROMETHOXYBENZYLIDENE)-MALONONITRILE(474759-76-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 474759-76-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-(4-TRIFLUOROMETHOXYBENZYLIDENE)-MALONONITRILE is used as a reactive intermediate for the synthesis of complex organic molecules, leveraging its unique structure and properties to facilitate the formation of new compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(4-TRIFLUOROMETHOXYBENZYLIDENE)-MALONONITRILE is utilized as a key component in drug discovery and development. Its potential for creating new therapeutic agents is attributed to its ability to be incorporated into diverse molecular frameworks, which can be optimized for specific medicinal properties.
Used in Material Science:
2-(4-TRIFLUOROMETHOXYBENZYLIDENE)-MALONONITRILE is employed as a building block in the development of new materials with unique properties. Its incorporation into material frameworks can lead to advancements in areas such as polymer science, nanotechnology, and other material-based applications.

Upstream product

• 659-28-9 p-trifluoromethoxybenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 1019063-20-7 C₂₁H₁₁F₃N₂O₄ 
• 1227682-17-8 C₂₆H₁₈ClF₃N₆O₄ 
• 1204653-96-2 C₂₁H₁₆ClF₃N₆O₃ 
• 791619-90-4 2-amino-4-(4-trifluoromethoxyphenyl)-6-mercaptopyridine-3,5-dicarbonitrile 
• 791619-82-4 2-amino-4-(4-trifluoromethoxyphenyl)-6-phenylsulfanylpyridine-3,5-dicarbonitrile 

Relevant articles and documents

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with anticancer activity

4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes,

Design, multicomponent synthesis, and bioactivities of novel neonicotinoid analogues with 1,4-dihydropyridine scaffold

Novel neonicotinoid analogues bearing a 1,4-dihydropridine scaffold were designed and synthesized by multicomponent reactions (MCRs) to enhance π-π stacking. The synthesized compounds were identified by 1H NMR, 13C NMR, high-resoluti

Designing tetrahydroimidazo[1,2- a ]pyridine derivatives via catalyst-free Aza-Diels-Alder Reaction (ADAR) and their insecticidal evaluation

A series of tetrahydroimidazo[1,2-a]pyridine derivatives were synthesized by the reaction of 2-vinyl-4,5-dihydroimidazole derivatives with substituted benzylidenemalononitrile via a catalyst-free aza-Diels-Alder reaction. Insecticidal activities of target

A series of ligands displaying a remarkable agonistic-antagonistic profile at the adenosine A1 receptor

Adenosine receptor agonists are usually variations of the natural ligand, adenosine. The ribose moiety in the ligand has previously been shown to be of great importance for the agonistic effects of the compound. In this paper, we present a series of nonadenosine ligands selective for the adenosine A 1 receptor with an extraordinary pharmacological profile. 2-Amino-4-benzo-[1,3]dioxol-5-yl-6-(2-hydroxyethylsulfanyl)pyridine-3, 5-dicarbonitrile (70, LUF 5853) shows full agonistic behavior comparable with the reference compound CPA, while also displaying comparable receptor binding affinity (Ki = 11 nM). In contrast, compound 58 (2-amino-4-(3- trifluoromethylphenyl)-6-(2-hydroxyethylsulfanyl)pyridine-3,5-dicarbonitrile, LUF 5948) has a binding affinity of 14 nM and acts as an inverse agonist. Also present within this same series are compounds that show neutral antagonism of the adenosine A1 receptor, for example compound 65 (2-amino-4-(4-difluoromethoxyphenyl)-6-(2-hydroxyethylsulfanyl)pyridine-3, 5-dicarbonitrile, LUF 5826).