475060-43-6

Basic information

• Product Name: TETRAHYDRO-3-(IODOMETHYL)-FURAN
• Synonyms: TETRAHYDRO-3-(IODOMETHYL)-FURAN;3-(Iodomethyl)-tetrahydrofuran;3-(iodomethyl)oxolane;3-(Iodomethyl)
• CAS NO: 475060-43-6
• Molecular Formula: C₅H₉IO
• Molecular Weight: 212.03
• Mol File: 475060-43-6.mol

Chemical Properties

• Boiling Point: 208℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.772
• Vapor Pressure: 0.309mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: TETRAHYDRO-3-(IODOMETHYL)-FURAN(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-3-(IODOMETHYL)-FURAN(475060-43-6)
• EPA Substance Registry System: TETRAHYDRO-3-(IODOMETHYL)-FURAN(475060-43-6)

Safety Data

• Hazardous Substances Data: 475060-43-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
TETRAHYDRO-3-(IODOMETHYL)-FURAN is used as a building block in organic synthesis for its high reactivity and the ability to undergo a wide range of chemical transformations.
Used in Pharmaceutical Production:
In the pharmaceutical industry, TETRAHYDRO-3-(IODOMETHYL)-FURAN is used as an intermediate in the production of various drugs, contributing to the development of new medicinal compounds.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, TETRAHYDRO-3-(IODOMETHYL)-FURAN serves as an intermediate, playing a role in the synthesis of compounds used in agricultural chemicals to protect crops and enhance yields.

InChI:InChI=1/C5H9IO/c6-3-5-1-2-7-4-5/h5H,1-4H2

Upstream product

• 65805-36-9 3-(2-iodoethoxy)prop-1-ene 
• 15833-63-3 (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate 
• 124391-75-9 3-tetrahydrofuranmethanol 
• 184849-49-8 (tetrahydrofuran-3-yl)methyl methanesulfonate 
• 4443-40-7 phthaloylasparic anhydride 

Downstream Products

• 1080061-17-1 methyl 2-[4-(methylsulfonyl)phenyl]-3-(tetrahydrofuran-3-yl)propanoate 
• 1174229-20-9 triphenyl(tetrahydrofuran-3-ylmethyl)phosphonium iodide 
• 1262512-78-6 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-3-methoxy-5-(tetrahydro-furan-3-ylmethyl)cyclopent-2-enone 
• 625112-74-5 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(tetrahydro-furan-3-yl)-propionic acid 

Relevant articles and documents

Bismuth Compounds in Radical Catalysis: Transition Metal Bismuthanes Facilitate Thermally Induced Cycloisomerizations

The controlled radical chemistry of bismuth compounds is still in its infancy. Further developments are fueled by the properties of these complexes (e.g., low toxicity, high functional group tolerance, low homolytic bond dissociation energies, and reversible homolytic bond dissociations), which are highly attractive for applications in synthetic chemistry. Here we report the first catalytic application of transition metal bismuthanes (i.e. compounds with a Bi–TM bond; TM=transition metal). Using the catalyzed radical cyclo-isomerization of δ-iodo-olefins as a model reaction, characteristics complementary or superior to known B, Mn, Cu, Zn, Sn, and alkali metal reagents are demonstrated (including a different crucial intermediate), establishing transition metal bismuthanes as a new class of (pre-)catalysts for controlled radical reactions.

2- PYRIDONE COMPOUND

PROBLEM TO BE SOLVED: To provide a compound that has excellent glucokinase (GK) activating action and is useful as a pharmaceutical. SOLUTION: The present invention provides a 2-pyridone compound represented by formula [1], and a tautomer or stereoisomer of the compound, or their pharmacologically acceptable salts, or their solvates (where R1 is RA-ZA-; RA is any of a carboxy group, a sulfo group or formula [5]). COPYRIGHT: (C)2016,JPOandINPIT

Pyrazole glucokinase activators

Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.

Synthesis of bicyclic tertiary α-amino acids

Novel bicyclic α-amino acids, exo and endo-1-azabicyclo-[2.2.1] heptane-2-carboxylic acid, 1-azabicyclo[2.2.1]heptane-7-carboxylic acid, and 1-azabicyclo[3.2.2]nonane-2-carboxylic acid have been readily synthesized for the generation of neuronal nicotinic receptor ligands. Alkylation of glycine-derived Schiff bases or nitroacetates with cyclic ether electrophiles, followed by acid-induced ring opening and cyclization in NH4OH, allowed for the preparation of substantial quantities of the three tertiary bicyclic α-amino acids.

Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

DESIGN AND SYNTHETIC APPLICATIONS OF NEW HETEROMETALLACYCLES

The reaction of cyclic anhydrides with Ni(0) complexes lead to the formation of nickelacycles by oxidative addition followed by decarbonylation.The preparation of chiral nickelacycles from anhydrides derived from amino acids and their reactivity is described.The formation of new heteropalladacycles by C-H activation or transmetallation reactions and their reactivity will be also discussed.