475150-60-8

Basic information

• Product Name: N-(2-chloro-4-formylphenyl)acetamide
• Synonyms: N-(2-chloro-4-formylphenyl)acetamide
• CAS NO: 475150-60-8
• Molecular Formula: C₉H₈ClNO₂
• Molecular Weight: 198
• Mol File: 475150-60-8.mol

Chemical Properties

• Boiling Point: 393.2±32.0 °C(Predicted)
• Appearance: /
• Density: 1.352±0.06 g/cm3(Predicted)
• PKA: 13.71±0.70(Predicted)
• CAS DataBase Reference: N-(2-chloro-4-formylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chloro-4-formylphenyl)acetamide(475150-60-8)
• EPA Substance Registry System: N-(2-chloro-4-formylphenyl)acetamide(475150-60-8)

Safety Data

• Hazardous Substances Data: 475150-60-8(Hazardous Substances Data)

Upstream product

• 122-85-0 para-acetamidobenzaldehyde 
• 556-18-3 4-aminobenzaldehyde 

Relevant articles and documents

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

Halogenated antituberculosis agents

Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure I: wherein X1is a halogen and X2is a second halogen or hydrogen, and Y is sulfur or oxygen; or, has the structure of Structure IV: wherein X1is a halogen and X2is a second halogen or hydrogen. Alternatively, the halogenated compounds may be pharmaceutically acceptable salts of these compounds. These halogenated derivatives possess anti-mycobacterial activity and are particularly useful for the treatment of Mycobacterium tuberculosis infections. In particular, fluorinated analogs of thioacetazone and p-amino-salicylic acid have been synthesized for use as anti-tuberculosis therapeutic agents either alone or in combination with other conventional anti-tuberculosis therapeutic agents.