475275-69-5

Basic information

• Product Name: (5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID
• Synonyms: 5-CHLORO-2-METHOXY-PYRIDINE-4-BORONIC ACID;5-CHLORO-2-METHOXYPYRIDIN-4-YL-4-BORONIC ACID;(5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID;Boronic acid, (5-chloro-2-methoxy-4-pyridinyl)- (9CI);(5-Chloro-2-Methoxy-4-pyridyl)boronic acid;Boronic acid, B-(5-chloro-2-methoxy-4-pyridinyl)-
• CAS NO: 475275-69-5
• Molecular Formula: C₆H₇BClNO₃
• Molecular Weight: 187.39
• Product Categories: BORONICACID
• Mol File: 475275-69-5.mol

Chemical Properties

• Boiling Point: 347.608 °C at 760 mmHg
• Flash Point: 164.028 °C
• Appearance: /
• Density: 1.403 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID(475275-69-5)
• EPA Substance Registry System: (5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID(475275-69-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 475275-69-5(Hazardous Substances Data)

Usage

Uses

5-Chloro-2-methoxypyridine-4-boronic acid

InChI:InChI=1/C6H7BClNO3/c1-12-6-2-4(7(10)11)5(8)3-9-6/h2-3,10-11H,1H3

Upstream product

• 13473-01-3 5-chloro-2-methoxypyridine 
• 5419-55-6 Triisopropyl borate 
• 121-43-7 Trimethyl borate 

Downstream Products

• 1621525-22-1 5-chloro-4-(3-iodo-1H-pyrazol-1-yl)-2-methoxypyridine 

Relevant articles and documents

SUBSTITUTED OXOPYRIDINE DERIVATIVES

The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

SUBSTITUTED OXOPYRIDINE DERIVATIVES

The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

SUBSTITUTED OXOPYRIDINE DERIVATIVES

The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Method for preparing aromatic boronic acid

The invention discloses a method for preparing aromatic ring boric acid, which comprises the following steps of: (1) firstly, leading the mixed solution of aromatic ring compounds, n-butyllithium and a chelant with nitrogen heterocycle to have a reaction

Substituted Oxopyridine Derivatives and Use Thereof in the Treatment of Cardiovascular Disorders

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

SUBSTITUTED OXOPYRIDINE DERIVATIVES

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Functionalized pyridylboronic acids and their Suzuki cross-coupling reactions to yield novel heteroarylpyridines

2-Bromo-5-pyridylboronic acid 2a, 2-chloro-5-pyridylboronic acid 2b, 2-methoxy-5-pyridylboronic acid 2c, and 5-chloro-2-methoxy-4-pyridylboronic acid 4 have been synthesized and shown to undergo palladium-catalyzed cross-coupling reactions with heteroaryl bromides to yield novel heteroarylpyridine derivatives. The X-ray crystal structures of 2a and 2b have been obtained.