476296-31-8Relevant articles and documents
NOVEL BIARYLAMIDE DERIVATIVE AND COMPOSITIONS CONTAINING THE DERIVATIVE AS AN ACTIVE INGREDIENT
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Page/Page column 11, (2012/12/13)
The present invention relates to a novel biarylamide derivative and a pharmaceutical composition or a cosmetic composition comprising the same as an active ingredient. More particularly, the present invention relates to a novel biarylamide derivative, a pharmaceutical composition or a cosmetic composition for preventing or treating a pigmentation disorder caused by an abnormal excess of melanin or a disease caused by melanocyte hyperplasia comprising the same as an active ingredient. The biarylamide derivative of the present invention inhibits melanin production and thus inhibits melanocyte hyperplasia. Therefore, a cosmetic composition comprising the biarylamide is excellent in a whitening effect, and a pharmaceutical composition comprising the biarylamide is effective in the prevention or treatment of pigmentation disorders of skin such as lentigo, melasma, freckle, etc. and malignant melanoma.
Identification of a potent and noncytotoxic inhibitor of melanin production
Hwang, Soonho,Choi, Sang Yoon,Lee, Jin Hee,Kim, Shinae,In, Jinkyung,Ha, Sang Keun,Lee, Eunjung,Kim, Tae-Yoon,Kim, Sun Yeou,Choi, Sun,Kim, Sanghee
experimental part, p. 5602 - 5609 (2010/09/14)
On the basis of a hit from random screening, biaryl amide derivatives were prepared in a combinatorial manner via parallel solution-phase synthesis, and their effects on melanocytes were investigated to discover new effective skin depigmenting agents. Amo