476493-08-0Relevant articles and documents
PYRIDO[3,4-B]PYRAZINE DERIVATIVES AS SYK INHIBITORS
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Paragraph 0693; 0694; 0695, (2014/02/15)
A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, and autoimmune conditions.
PYRIDO[3,4-B]PYRAZINE DERIVATIVES AS SYK INHIBITORS
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Page/Page column 85-86, (2012/10/07)
A compound of formula (I) or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, and autoimmune conditions.
QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS
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Page/Page column 137-138, (2008/06/13)
A quinazoline derivative of the formula (I): (A chemical formula should be inserted here - please see paper copy enclosed) Formula I wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.
CHEMICAL COMPOUNDS
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Page 200, (2010/02/09)
Quinazoline derivatives of formula (I); for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in the treatment of proliferative diseases, and to processes for their preparation, as well as pharmaceutical compositions containing them as active ingredient.