- Propenone derivatives
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The present invention relates to propenone derivatives represented by the following formula (I): STR1 wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR5 (wherein Y represents S or O; and R5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R2 and R3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R2 and R3 are combined to form substituted or unsubstituted methylene or ethylene; R4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.
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- TIN-THALL REACTION, A VERSATILE METHOD FOR CROSS COUPLING TIN COMPOUNDS WITH THALLIUM COMPOUNDS
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A new cross coupling reaction between tin compounds and thallium compounds is developed and its versatility is demonstrated by the convenient synthesis of various 4-substituted indoles.KEYWORDS - tin-thall reaction; thallation-palladation; cross coupling; 4-substituted indole; thallium compound; tin compound; palladium acetate; 4-(3-pyridyl)-3-indolecarbaldehyde
- Somei, Masanori,Yamada, Fumio,Naka, Katsumi
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p. 1322 - 1326
(2007/10/02)
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