- Regioselective addition of Grignard reagents to N-acylpyrazinium salts: Synthesis of substituted 1,2-dihydropyrazines and Δ5-2-oxopiperazines
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The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihy-dropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines can be converted to substituted Δ5-2-oxopiperazines providing a simple and efficient approach towards their preparation.
- St Hilaire, Valentine R.,Hopkins, William E.,Miller, Yenteeo S.,Dandepally, Srinivasa R.,Williams, Alfred L.
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supporting information
p. 72 - 78
(2019/01/28)
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- SYK INHIBITORS
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The present disclosure a Syk compound inhibitors, including state cancer and inflammation and various disease States thereof in the treatment of relates to the use of. In one aspect a particular embodiment, . given by formula I which is marked as a chemical structure of compound. In formula said, X 1, X 2, X 3, R 2, R 3, R 4, R 5, and Y has described herein is. The present disclosure of a formula I compounds or a pharmaceutically acceptable salt of pharmaceutical compositions including, mediated by Syk and to treat conditions a employing these compounds and compositions further provides a method. (by machine translation)
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Paragraph 2821-2823
(2016/10/07)
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- Synthesis of mono- and diaza-'pyridones' via stille coupling of alkoxystannanes
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Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted 'pyridone' moieties via Stille cross-coupling. Both pyridyl and a series of diazinyl stannanes are prepared, and options for unmasking (via demethylation or debenzylation) of the pyridone unit are evaluated. Georg Thieme Verlag Stuttgart. New York.
- Smith, Charlotte L.,Hirschh?user, Christoph,Malcolm, Georgia K.,Nasrallah, Daniel J.,Gallagher, Timothy
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p. 1904 - 1908
(2014/08/18)
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- Selective Ligands for the Neuronal Nicotinic Receptors and Uses Thereof
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The present application describes selective ligands of formula (I) for neuronal nicotinic receptors (NNRs), more specifically for the α4β2 NNR subtype, compositions thereof, and methods of using the same, wherein X, R1, X, R2, R3, L1, m, n, p, and q are defined in the specification.
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Page/Page column 16
(2009/12/04)
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- Alkanesulfonate derivatives and their use as insecticides, acaricides or nematicides
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Disclosed herein is a compound of the formula: wherein Ar is pyridine ring, pyridazine ring, pyrimidine ring, pyrazine ring, isoquinoline ring or thiazole ring, and those rings may be substituted by 1?3 of substituents selected from the group consisting of halogen, C1 ?C4 -alkyl, C1 ?C4 -alkoxy, CF3 and nitro, R1 is C1 ?C8 -alkyl; C1 ?C7 -alkyl which is substituted by 1?3 of F, Cl or Br, C1 ?C4 -alkoxy or C1 ?C4 -alkylthio; C3 ?C7 -cycloalkyl which may be substituted by 1?4 of F, Cl or methyl; C3 ?C6 -cycloalkylmethyl which may be substituted by 1?4 of F, Cl, Br or methyl; allyl, propargyl, phenyl or benzyl; R2 is C1 ?C4 -alkyl which may be substituted by 1?3 of F or Cl, x is integer of 0, 1 or 2, excepting wherein Ar is pyridine ring which is substituted by R1 --S(O)x and --O--SO2 R2 at 2- and 6-position and the R1 is C1 ?C7 -alkyl and the pyridine ring is not further substituted or substituted by 1?3 of halogen.
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