- Concise preparation of amino-5,6,7,8-tetrahydroquinolines and amino-5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of acetamidoquinolines and acetamidoisoquinolines
-
A method to prepare amino-substituted 5,6,7,8- tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of the corresponding acetamido-substituted quinolines and isoquinolines followed by acetamide hydrolysis is described. The
- Skupinska, Krystyna A.,McEachern, Ernest J.,Skerlj, Renato T.,Bridger, Gary J.
-
p. 7890 - 7893
(2007/10/03)
-
- Synthesis and dopaminergic activity of heterocycli analogues of 5,6-dihydroxy-2-aminotetralins
-
The heterocyclic analogues of 5,6-dihydroxy-2-aminotetralins (6) were synthesized and their in vitro dopaminergic activity was compared to that of (-)-DP-5,6-ADTN and the novel potent agonist Z12571. The results show that changing the cathecol ring for a heterocycle decreases the D1-like activity of the target molecules 6. However, the D2-like activity of tetra-hydroquinoline (6j) was comparable to that of (-)-DP-5,6-ADTN. (C) 2000 Elsevier Science Ltd. All rights reserved.
- Bosch, Joan,Roca, Tomas,Perez, Carles G.,Montanari, Stefania
-
p. 563 - 566
(2007/10/03)
-