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477872-36-9

1-[(4-BROMOPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 477872-36-9 Structure

  • Basic information

    1. Product Name: 1-[(4-BROMOPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE
    2. Synonyms: 1-[(4-BROMOPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE;1-(4-bromobenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine
    3. CAS NO:477872-36-9
    4. Molecular Formula: C13H9BrN2O2S
    5. Molecular Weight: 337.19
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 477872-36-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-[(4-BROMOPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-[(4-BROMOPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE(477872-36-9)
    11. EPA Substance Registry System: 1-[(4-BROMOPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE(477872-36-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 477872-36-9(Hazardous Substances Data)

477872-36-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 477872-36-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,7,8,7 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 477872-36:
(8*4)+(7*7)+(6*7)+(5*8)+(4*7)+(3*2)+(2*3)+(1*6)=209
209 % 10 = 9
So 477872-36-9 is a valid CAS Registry Number.

477872-36-9Relevant articles and documents

Synthesis and evaluation of biological activities of new sulfonamide and carbamate derivatives of 1H-pyrrolo[2,3-b]pyridine (7-azaindole)

Sudhamani,Thaslim Basha,Muni Chandra Reddy,Sreedhar,Adam,Naga Raju

, p. 7471 - 7486 (2016)

Abstract: Synthesis of a new series of sulfonamide and carbamate derivatives of 7-azaindole and evaluation of their anti-TMV and anti-oxidant activities are reported. Their chemical structures were characterized by IR, 1H and 13C NMR

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, Hsueh-Yun,Tsai, An-Chi,Chen, Mei-Chuan,Shen, Po-Jung,Cheng, Yun-Ching,Kuo, Ching-Chuan,Pan, Shiow-Lin,Liu, Yi-Min,Liu, Jin-Fen,Yeh, Teng-Kuang,Wang, Jing-Chi,Chang, Chi-Yen,Chang, Jang-Yang,Liou, Jing-Ping

, p. 4009 - 4022 (2014/06/09)

A series of indolylsulfonylcinnamic hydroxamates has been synthesized. Compound 12, (E)-3-(3-((1H-pyrrolo[2,3-b]pyridin-1-yl)sulfonyl)phenyl)-N- hydroxyacrylamide, which has a 7-azaindole core cap, was shown to have antiproliferative activity against KB, H460, PC3, HSC-3, HONE-1, A549, MCF-7, TSGH, MKN45, HT29, and HCT116 human cancer cell lines. Pharmacological studies indicated that 12 functions as a potent HDAC inhibitor with an IC50 value of 0.1 μM. It is highly selective for histone deacetylase 6 (HDAC6) and is 60-fold more active than against HDAC1 and 223-fold more active than against HDAC2. It has a good pharmacokinetic profile with oral bioavailability of 33%. In in vivo efficacy evaluations in colorectal HCT116 xenografts, compound 12 suppresses tumor growth more effectively than SAHA (1, N-hydroxy-N′- phenyloctanediamide) and is therefore seen as a suitable candidate for further investigation.

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