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477872-94-9

2-(4-Methoxybenzyl)-1,3-thiazole-4-carboxylic acid is a chemical compound characterized by the molecular formula C14H13NO3S. It is a thiazole derivative featuring a carboxylic acid functional group and a methoxybenzyl substituent. 2-(4-METHOXYBENZYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID holds promise in the pharmaceutical industry as a building block for the synthesis of various drug candidates. Its unique structural features, including the presence of a thiazole ring, suggest potential antimicrobial and antifungal properties, making it a valuable intermediate in the development of biologically active compounds with diverse applications.

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  • 477872-94-9 Structure

  • Basic information

    1. Product Name: 2-(4-METHOXYBENZYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
    2. Synonyms: 2-(4-METHOXYBENZYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-[(4-methoxyphenyl)methyl]-1,3-thiazole-4-carboxylic acid
    3. CAS NO:477872-94-9
    4. Molecular Formula: C12H11NO3S
    5. Molecular Weight: 249.29
    6. EINECS: N/A
    7. Product Categories: Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles
    8. Mol File: 477872-94-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(4-METHOXYBENZYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(4-METHOXYBENZYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(477872-94-9)
    11. EPA Substance Registry System: 2-(4-METHOXYBENZYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(477872-94-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 477872-94-9(Hazardous Substances Data)

477872-94-9 Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Methoxybenzyl)-1,3-thiazole-4-carboxylic acid is used as a building block for the synthesis of drug candidates due to its unique structural features and potential biological activity.
Used in Antimicrobial Applications:
2-(4-Methoxybenzyl)-1,3-thiazole-4-carboxylic acid is used as an antimicrobial agent, leveraging its potential to inhibit the growth of bacteria and other microorganisms, thanks to the presence of the thiazole ring in its structure.
Used in Antifungal Applications:
2-(4-Methoxybenzyl)-1,3-thiazole-4-carboxylic acid is used as an antifungal agent, indicating its potential to combat fungal infections and control the growth of fungi.
Used in Chemical Intermediates:
2-(4-Methoxybenzyl)-1,3-thiazole-4-carboxylic acid is used as a valuable chemical intermediate in the development of biologically active compounds, contributing to the creation of new pharmaceuticals and other bioactive substances.

Check Digit Verification of cas no

The CAS Registry Mumber 477872-94-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,7,8,7 and 2 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 477872-94:
(8*4)+(7*7)+(6*7)+(5*8)+(4*7)+(3*2)+(2*9)+(1*4)=219
219 % 10 = 9
So 477872-94-9 is a valid CAS Registry Number.

477872-94-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-Methoxybenzyl)-1,3-thiazole-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:477872-94-9 SDS

477872-94-9Downstream Products

477872-94-9Relevant articles and documents

Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor

Jung, Hui Jin,Nam, Eun Hye,Park, Jin Young,Ghosh, Prithwish,Kim, In Su

, (2021/02/26)

Fibroblast activation protein (FAP) belongs to the family of prolyl-specific serine proteases and displays both exopeptidase and endopeptidase activities. FAP expression is undetectable in most normal adult tissues, but is greatly upregulated in sites of tissue remodeling, which include fibrosis, inflammation and cancer. Due to its restricted expression pattern and dual enzymatic activities, FAP inhibition is investigated as a therapeutic option for several diseases. In the present study, we described the structure–activity relationship of several synthesized compounds against DPPIV and prolyl oligopeptidase (PREP). In particular, BR102910 (compound 24) showed nanomolar potency and high selectivity. Moreover, the in vivo FAP inhibition study of BR102910 (compound 24) using C57BL/6J mice demonstrated exceptional profiles and satisfactory FAP inhibition efficacy. Based on excellent in vitro and in vivo profiles, the potential of BR102910 (compound 24) as a lead candidate for the treatment of type 2 diabetes is considered.

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