478182-28-4

Basic information

• Product Name: 4'-Azidocytidine
• Synonyms: 4'-Azidocytidine;R-1479;4'-alpha-Azido-cytidine;Cytidine, 4'-C-azido-;4'-C-azidocytidine
• CAS NO: 478182-28-4
• Molecular Formula: C₉H₁₂N₆O₅
• Molecular Weight: 284.22878
• Mol File: 478182-28-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-Azidocytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Azidocytidine(478182-28-4)
• EPA Substance Registry System: 4'-Azidocytidine(478182-28-4)

Safety Data

• Hazardous Substances Data: 478182-28-4(Hazardous Substances Data)

Usage

Uses

Used in Antiviral Applications:
4'-Azidocytidine is used as an antiviral agent for its ability to inhibit viral polymerase, thereby disrupting the replication process of various viruses, such as SARS-CoV-2. This makes it a promising candidate for antiviral drug development.
Used in Cancer Therapy:
4'-Azidocytidine is used as an anti-cancer agent, potentially targeting cancer cells and inhibiting their growth. Its exact mechanism in cancer treatment is still under investigation, but its potential in this area is being explored in ongoing studies.
Used in Pharmaceutical Research:
4'-Azidocytidine is used as a research compound for studying its antiviral and anti-cancer properties. This helps scientists understand its therapeutic potential and side effects, which is crucial for the development of new drugs and treatments.

Upstream product

• 690270-27-0 acetic acid (2R,2S,4R,5R)-4-acetoxy-2-acetoxymethyl-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azidotetrahydrofuran-3-yl ester 
• 690271-25-1 (2R,3R,4S,5R)-4-acetoxy-5-acetoxymethyl-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydrofuran-3-yl acetate 
• 478182-26-2 C₂₃H₁₉N₅O₈ 
• 139442-01-6 1-(4'-azido-β-D-ribofuranosyl)uracil 
• 139419-04-8 4'-azido-5'-deoxy-5'-iodouridine 
• 139419-02-6 4'-azido-2',3'-di-O-benzoyl-5'-deoxy-5'-iodouridine 
• 58-96-8 uridine 
• 14365-63-0 5'-deoxyuridin-4'-ene 
• 690270-09-8 benzoic acid (2R,3S,4R,5R)-2-azido-3,4-dibenzoyloxy-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydrofuran-2-ylmethyl ester 

Downstream Products

• 690270-29-2 balapiravir 
• 1186412-30-5 C₂₅H₂₇ClN₇O₉P 
• 1186412-24-7 C₂₂H₃₀N₇O₉P 
• 1186412-08-7 C₂₉H₃₄N₇O₉P 

Relevant articles and documents

4'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF EBOLA VIRUS RNA REPLICATION

The application discloses compounds of Formula I wherein the variable substituents are as defined herein. The compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I are useful for the treatment of diseases mediated by Filoviruses such as Ebolavirus.

Azido nucleosides and nucleotide analogs

Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

AZIDO NUCLEOSIDES AND NUCLEOTIDE ANALOGS

Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of amelioratin

The design, synthesis, and antiviral activity of 4′-azidocytidine analogues against hepatitis C virus replication: The discovery of 4′-azidoarabinocytidine

4′-Azidocytidine 3 (R1479) has been previously discovered as a potent and selective inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B. Here we describe the synthesis and biological evaluation of several der

PROCESS FOR PREPARATION OF 4'-AZIDO CYTIDINE DERIVATIVES

The invention relates to a novel process for the preparation of a 4'-azido cytidine of the formula (I) of a hydrate or of a pharmaceutically accepted salt thereof. The 4'-azido cytidine of formula (I) is useful for treating virus mediated diseases, particularly for treating HCV mediated diseases.

Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479

A series of 4′-substituted ribonucleoside derivatives has been prepared and evaluated for inhibition of hepatitis C virus (HCV) RNA replication in cell culture. The most potent and non-cytotoxic derivative was compound 28 (4′-azidocytidine, R1479) with an

4'-substituted nucleoside derivatives as inhibitors of HCV RNA replication

The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically a