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478258-60-5

4-(BENZYLSULFANYL)-6-CHLORO-2-PYRIMIDINAMINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 478258-60-5 Structure

  • Basic information

    1. Product Name: 4-(BENZYLSULFANYL)-6-CHLORO-2-PYRIMIDINAMINE
    2. Synonyms: 4-(BENZYLSULFANYL)-6-CHLORO-2-PYRIMIDINAMINE;4-(BENZYLSULFANYL)-6-CHLORO-2-PYRIMIDINYLAMINE;4-(benzylsulfanyl)-6-chloropyrimidin-2-amine
    3. CAS NO:478258-60-5
    4. Molecular Formula: C11H10ClN3S
    5. Molecular Weight: 251.74
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 478258-60-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(BENZYLSULFANYL)-6-CHLORO-2-PYRIMIDINAMINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(BENZYLSULFANYL)-6-CHLORO-2-PYRIMIDINAMINE(478258-60-5)
    11. EPA Substance Registry System: 4-(BENZYLSULFANYL)-6-CHLORO-2-PYRIMIDINAMINE(478258-60-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 478258-60-5(Hazardous Substances Data)

478258-60-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 478258-60-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,8,2,5 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 478258-60:
(8*4)+(7*7)+(6*8)+(5*2)+(4*5)+(3*8)+(2*6)+(1*0)=195
195 % 10 = 5
So 478258-60-5 is a valid CAS Registry Number.

478258-60-5Relevant articles and documents

METHODS OF TREATING SEROTONIN-MEDIATED DISEASES AND DISORDERS

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, (2009/01/24)

Methods are disclosed for treating serotonin-mediated diseases and disorders, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.

METHODS OF USING AND COMPOSITIONS COMPRISING TRYPTOPHAN HYDROXYLASE INHIBITORS

-

, (2009/01/24)

Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some drugs.

METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN

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, (2009/02/11)

Methods and compounds are disclosed for affecting gastrointestinal motility and gastric emptying, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.

Multicyclic amino acid derivatives and methods of their use

-

Page/Page column 36, (2010/11/28)

Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:

The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase I

Gibson, Colin L.,La Rosa, Salvatore,Ohta, Kyuji,Boyle, Peter H.,Leurquin, Fabien,Lema?on, Alexandra,Suckling, Colin J.

, p. 943 - 959 (2007/10/03)

Variously substituted 7-deazaguanines are of interest as inhibitors of GTP cyclohydrolase I, the first enzyme in the biosynthetic pathway leading to dihydrofolate and tetrahydrobiopterin. Methods are described for the synthesis of 7-deazaguanines substituted at positions 2, 6 and 9 (purine numbering) such that a wide diversity of compounds can be prepared. These methods supplement our previous work that established routes for the synthesis of 7- and 8-substituted 7-deazaguanines. Emphasis is placed on the properties of 2-thioalkyl pyrimidines as intermediates because they provide the basis for a traceless solid-state synthesis of purines, pteridines, and their analogues. Compounds prepared have been assessed in a primary screen for their ability to inhibit GTPCH I and 8-methyldeazaguanine has been shown to be significantly more potent than any inhibitor yet described. Several compounds appeared to undergo transformation by GTPCH I; with the aid of a model reaction, their behaviour can be interpreted in the context of the mechanism of the hydrolytic phase of GTPCH I.

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