N-aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: Further probing of the S1, S1′, and S2′ pockets
A series of N-arylsulfonyl S-alkyl homocysteine hydroxamic acids were synthesized with variations in three subsites corresponding to P1, P1′, and P2′. Enzyme assays with a variety of MMPs revealed activity at the low nanomolar level.
Hanessian,Moitessier,Gauchet,Viau
p. 3066 - 3073
(2007/10/03)
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