479091-07-1

Basic information

• Product Name: Benzamide, 2,4-difluoro-3-hydroxy-
• Synonyms: Benzamide, 2,4-difluoro-3-hydroxy-
• CAS NO: 479091-07-1
• Molecular Formula: C₇H₅F₂NO₂
• Molecular Weight: 173.12
• Mol File: 479091-07-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzamide, 2,4-difluoro-3-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2,4-difluoro-3-hydroxy-(479091-07-1)
• EPA Substance Registry System: Benzamide, 2,4-difluoro-3-hydroxy-(479091-07-1)

Safety Data

• Hazardous Substances Data: 479091-07-1(Hazardous Substances Data)

Upstream product

• 479091-06-0 2,4-difluoro-3-methoxybenzamide 

Downstream Products

• 479091-08-2 3-difluoromethoxydifluorobenzamide 

Relevant articles and documents

ANTIBACTERIAL AGENTS

Compounds of formula (I) have antibacterial activity wherein R represents hydrogen or 1, 2 or 3 optional substituents; W is =C(R1)- or =N-; R1 is hydrogen or an optional substituent and R2 is hydrogen, methyl, or fluorine; or R1 and R2 taken together are -CH2-, -CH2CH2-, -O-, or, in either orientation, -O- CH2- Or -OCH2CH2-; R3 is a radical of formula -(Alk1)m-(Z)p-(Alk2)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z is -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, -N(CH2CH3)-, -C(=O)-, -O-(C=O)-, -C(=O)-O-, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic heterocyclic radical having 5 to 10 ring atoms; Alk1 and Alk2 are optionally substituted C1C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, or -N(CH2CH3)-; and Q is hydrogen, halogen, nitrile, or hydroxyl or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic heterocyclic radical having 5 to 10 ring atoms.

Antibacterial agents

The present invention provides compounds of formula (I): wherein R1-R6 and J and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of formula I, processes for preparing compounds of formula I, and intermediates useful for preparing compounds of formula I.