Synthesis of 4-(1-phenylmethyl-5-imidazolyl)-1,4-dihydropyridines as calcium channel antagonists
o-Nitrophenyl group of nifedipine has been replaced with 2-alkylthio-1-phenylmethyl-5-imidazolyl substituent. Starting from dihydroxyacetone and phenylmethylamine hydrochloride, 2-alkythio-1-phenylmethyl-5-formylimidazole 3 is first synthesized and subsequently used in synthesizing symmetrical (5a-f) and asymmetrical (6a,b) dihydropyridines.
Hadizadeh,Shafiee,Kazemi,Mohammadi
p. 2679 - 2682
(2007/10/03)
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