479422-03-2 Usage
Uses
Used in Pharmaceutical Industry:
5,6-DICHLORO-2-METHYL-1H-INDOLE is used as a building block in the synthesis of pharmaceuticals for its potential role in the development of new therapeutic agents. Its chemical structure and properties make it a valuable ingredient in creating innovative medicines.
Used in Agrochemical Industry:
In the agrochemical industry, 5,6-DICHLORO-2-METHYL-1H-INDOLE is utilized as a component in the synthesis of agrochemicals, contributing to the development of effective products for agricultural applications.
Used in Organic Compounds Synthesis:
5,6-DICHLORO-2-METHYL-1H-INDOLE is used as a versatile building block in the synthesis of various organic compounds, showcasing its wide-ranging applicability in chemical research and development.
Used in Antifungal Applications:
5,6-DICHLORO-2-METHYL-1H-INDOLE has been studied for its potential as an antifungal agent, making it a candidate for use in treatments and products that combat fungal infections.
Used in Anti-inflammatory Applications:
5,6-DICHLORO-2-METHYL-1H-INDOLE has also been investigated for its potential anti-inflammatory properties, suggesting a possible use in the development of anti-inflammatory medications or therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 479422-03-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,9,4,2 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 479422-03:
(8*4)+(7*7)+(6*9)+(5*4)+(4*2)+(3*2)+(2*0)+(1*3)=172
172 % 10 = 2
So 479422-03-2 is a valid CAS Registry Number.
479422-03-2Relevant articles and documents
Inhibition of cytosolic phospholipase A2α: Hit to lead optimization
McKew, John C.,Foley, Megan A.,Thakker, Paresh,Behnke, Mark L.,Lovering, Frank E.,Sum, Fuk-Wah,Tam, Steve,Wu, Kun,Shen, Marina W. H.,Zhang, Wen,Gonzalez, Mario,Liu, Shanghao,Mahadevan, Anu,Sard, Howard,Khor, Soo Peang,Clark, James D.
, p. 135 - 158 (2007/10/03)
Compound 1 was previously reported to be a potent inhibitor of cPLA 2α in both artificial monomeric substrate and cell-based assays. However, 1 was inactive in whole blood assays previously used to characterize cyclooxygenase and lipoxygenase inhibitors. The IC50 of 1 increased dramatically with cell number or lipid/detergent concentration. In an attempt to insert an electrophilic ketone between the indole and benzole acid moieties, we discovered that increasing the distance between the two moieties gave a compound with activity in the GLU (7-hydroxycoumarinyl-γ- linolenate) micelle assay, which contains lipid and detergent. Extensive structure-activity relationship work around this lead identified a potent pharmacophore for cPLA2α inhibition. The IC50s between the GLU micelle and rat whole blood assays correlated highly. No correlation was found for other parameters, including lipophilicity or acidity of the required acid functionality. Compounds 25, 39, and 94 emerged as potent, selective inhibitors of cPLA2α and represent well-validated starting points for further optimization.
