2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidines as potential inhibitors of thymidylate synthase [1]
Classical, antifolate inhibitors of thymidylate synthase often suffer from a number of potential disadvantages when used as antitumor agents. These include impaired uptake due to an alteration of the active transport system required for cellular uptake, a
Gangjee, Aleem,Yu, Jianming,Kisliuk, Roy L.
p. 833 - 840
(2007/10/03)
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