481697-67-0Relevant articles and documents
Intermolecular coupling of alkenes to heterocycles via C-H bond activation
Tan, Kian L.,Park, Steve,Ellman, Jonathan A.,Bergman, Robert G.
, p. 7329 - 7335 (2004)
The intermolecular coupling of unactivated alkenes to a range of heterocycles using a Rh(I) catalyst was investigated. A variety of functional groups were incorporated into the alkene, including esters, nitriles, acetals, and phthalimide. Furthermore, the heterocycle tolerated substitution with both electron-rich and electron-deficient groups. The intermolecular coupling became possible after it was discovered that weak acids dramatically increase the rate of both the inter- and intramolecular reactions. An extensive optimization of additives was performed, and HCl·PCy3 (Cy = cyclohexyl) and HCl·P-t-Bu2Et were in general found to be the best additives for the reaction.
Intermolecular coupling of isomerizable alkenes to heterocycles via rhodium-catalyzed C-H bond activation
Tan, Kian L.,Bergman, Robert G.,Ellman, Jonathan A.
, p. 13964 - 13965 (2007/10/03)
This reports first intermolecular coupling of unactivated alkenes, including isomerizable alkenes, to a range of heterocycles using a Rh(I) catalyst. A variety of functional groups were incorporated, including esters, nitriles, and acetals. The intermolec