483358-46-9Relevant articles and documents
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines
Kawanaka, Yasufumi,Kobayashi, Kaoru,Kusuda, Shinya,Tatsumi, Tadashi,Murota, Masayuki,Nishiyama, Toshihiko,Hisaichi, Katsuya,Fujii, Atsuko,Hirai, Keisuke,Nishizaki, Minoru,Naka, Masao,Komeno, Masaharu,Nakai, Hisao,Toda, Masaaki
, p. 689 - 702 (2007/10/03)
The process of discovery and biological evaluation of α,β-unsaturated cyclic amidines, as selective inhibitors of inducible nitric oxide synthase (iNOS), is reported. Dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines were synthesized a
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: Synthesis and biological evaluation of dihydropyridin-2-imines
Kawanaka, Yasufumi,Kobayashi, Kaoru,Kusuda, Shinya,Tatsumi, Tadashi,Murota, Masanori,Nishiyama, Toshihiko,Hisaichi, Katsuya,Fujii, Atsuko,Hirai, Keisuke,Naka, Masao,Komeno, Masaharu,Nakai, Hisao,Toda, Masaaki
, p. 2291 - 2294 (2007/10/03)
Dihydropyridin-2-imines were synthesized and biologically evaluated both in vitro and in vivo using a nitric oxide inhibition assay. Compounds 1, 4, 5 and 7-11 exhibited potent activity in the inducible nitric oxide (iNOS) inhibition assay. Of these 5, 6,