- A selective chromogenic reagent for cyanide determination
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A chromogenic reagent for cyanide determination in water based on the reaction of this anion with a squaraine derivative functionalized with ether chains has been developed.
- Ros-Lis, Jose V.,Martinez-Manez, Ramon,Soto, Juan
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- Emergent Molecular Recognition through Self-Assembly: Unexpected Selectivity for Hyaluronic Acid among Glycosaminoglycans
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Oligophenylenevinylene (OPV)-based fluorescent (FL) chemosensors exhibiting linear FL responses toward polyanions were designed. Their application to FL sensing of glycosaminoglycans (heparin: HEP, chondroitin 4-sulfate: ChS, and hyaluronic acid: HA) revealed that the charge density encoded as the unit structure directs the mode of OPV self-assembly: H-type aggregate for HEP with 16-times FL increase and J-type aggregate for HA with 93-times FL increase, thus unexpectedly achieving the preferential selectivity for HA in contrast to the conventional HEP selective systems. We have found that the integral magnitude of three factors consisting of binding mechanism, self-assembly, and FL response can amplify the structural information on the target input into the characteristic FL output. This emergent property has been used for a novel molecular recognition system that realizes unconventional FL sensing of HA, potentially applicable to the clinical diagnosis of cancer-related diseases. An unexpectedly selective fluorescent (FL) chemosensor for hyaluronic acid (HA) was developed, where structural information on the target critically directs the mode of chemosensor self-assembly leading to the characteristic FL response (see picture). This system is potentially applicable to the clinical diagnosis of functional disorders such as cancer-related diseases involving the overexpression of HA.
- Noguchi, Takao,Roy, Bappaditya,Yoshihara, Daisuke,Sakamoto, Junji,Yamamoto, Tatsuhiro,Shinkai, Seiji
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supporting information
p. 5708 - 5712
(2016/05/09)
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- FLUORESCENT COMPOUND OR SALT THEREOF, AGENT OF DETECTING IONIC COMPOUND AND METHOD OF DETECTING IONIC COMPOUND
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PROBLEM TO BE SOLVED: To provide a new fluorescent compound showing aggregation induced emission or salt thereof, and an agent of detecting an ionic compound. SOLUTION: The present invention provides a fluorescent compound represented by the formula (1) o
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Paragraph 0074-0076
(2017/01/26)
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- Design, synthesis, linear and nonlinear photophysical properties of novel pyrimidine-based imidazole derivatives
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Novel donor-π-acceptor (D-π-A) and donor-π-acceptor-π-donor (D-π-A-π-D) type pyrimidine imidazole derivatives with flexible ether chains (L1 and L2) have been efficiently synthesized through improved Knoevenagel condensation and Ullmann reactions with high yields. Based on systematic photophysical investigations and theoretical calculations, the structure-property relationships can be described as follows: (1) the linear and nonlinear optical properties of the target chromophores change regularly with increasing the number of branches and the polarity of the solvents. (2) The single-substituted chromophore L2 exhibited a remarkable negative solvato-kinetic effect, while the double-substituted chromophore L1 showed a positive solvato-kinetic effect. Significant bathochromic shifting of the emission spectra and larger Stokes shifts were observed in polar solvents. (3) The two-photon absorption (TPA) cross-section results further demonstrated that their TPA cross section values (δ) increase notably with increasing branch number, and the presence of high π-delocalization could induce large size-scalable TPA enhancements. (4) By comprehensively considering the optical performance, cytotoxicity and solubility, L1 was identified as the better candidate for living cell (HepG2) imaging.
- Zhang, Qiong,Luo, Lei,Xu, Hong,Hu, Zhangjun,Brommesson, Caroline,Wu, Jieying,Sun, Zhaoqi,Tian, Yupeng,Uvdal, Kajsa
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p. 3456 - 3463
(2016/05/09)
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- Selective and sensitive chromogenic detection of trivalent metal cations in water
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An azopyridine derivative for the selective and sensitive chromogenic detection of trivalent metal cations in water is described.
- Lozano-Torres, Beatriz,El Sayed, Sameh,Costero, Ana M.,Gil, Salvador,Parra, Margarita,Martínez-Má?ez, Ramón,Sancenón, Félix
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supporting information
p. 498 - 500
(2016/04/26)
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- Light-induced protein dimerization by one- And two-photon activation of gibberellic acid derivatives in living cells
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We developed a highly efficient system for light-induced protein dimerization in live cells using photo-caged derivatives of the phytohormone gibberellic acid (GA3). We demonstrate the application of the photo-activatable chemical inducer of di
- Schelkle, Korwin M.,Griesbaum, Tristan,Ollech, Dirk,Becht, Steffy,Buckup, Tiago,Hamburger, Manuel,Wombacher, Richard
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supporting information
p. 2825 - 2829
(2015/03/04)
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- Synthesis, crystal structure and third-order nonlinear optical properties in the near-IR range of a novel stilbazolium dye substituted with flexible polyether chains
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A novel stilbazolium salt with flexible chains, trans- [4-[N,N-bis(2-(2- methoxyethoxy)ethyl)amino]styryl]-N-methylpyridinium tetraphenylborate, was designed, synthesized and fully characterized. Third-order nonlinear optical properties for the new stilba
- Li, Dandan,Yu, Daohui,Zhang, Qiong,Li, Shengli,Zhou, Hongping,Wu, Jieying,Tian, Yupeng
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p. 278 - 285
(2013/03/29)
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- Enzyme-responsive silica mesoporous supports capped with azopyridinium salts for controlled delivery applications
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The preparation of a new capped silica mesoporous material, Rh-Azo-S, for on-command delivery applications in the presence of target enzymes is described. The material consists of nanometric mesoporous MCM-41-like supports loaded with Rhodamine B and capp
- Mas, Núria,Agostini, Alessandro,Mondrag?n, Laura,Bernardos, Andrea,Sancen?n, Félix,Marcos, M. Dolores,Martínez-Má?ez, Ram?n,Costero, Ana M.,Gil, Salvador,Merino-Sanjuán, Matilde,Amor?s, Pedro,Orzáez, Mar,Pérez-Payá, Enrique
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p. 1346 - 1356
(2013/02/25)
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- Squaraines as Fluoro-Chromogenic Probes for Thiol-Containing Compounds and Their Application to the Detection of Biorelevant Thiols
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A highly selective colorimetric chemodosimeter for thiol-containing compounds in aqueous solutions is reported. The design protocol makes use of a highly specific reaction between thiols and the electrophilic four-membered ring of highly colored, fluoresc
- Ros-Lis, Jose V.,Garcia, Beatriz,Jimenez, Diego,Martinez-Manez, Ramon,Sancenon, Felix,Soto, Juan,Gonzalvo, Fernando,Valldecabres, M. Carmen
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p. 4064 - 4065
(2007/10/03)
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