The present invention relates to 2-(benzoylamino)benzoic acid derivatives of the formula I wherein the variants Ar, X and R are as described in the specification. The said compounds modulate the activity of peroxisome proliferator-activated receptors (PPAR) α and/or γ, and are predicted to be useful in the treatment of metabolic diseases, e.g. type II diabetes.
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(2008/06/13)
Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.
A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPARalpha/gamma activity. Both dual activators and selective PPARgamma agonists have been identified. This class of compounds was shown to activate the PPARgamma receptor through interaction with a novel binding site.
Thor, Markus,Beierlein, Katarina,Dykes, Graeme,Gustavsson, Anna Lena,Heidrich, Jessica,Jendeberg, Lena,Lindqvist, Bengt,Pegurier, Cecile,Roussel, Patrick,Slater, Martin,Svensson, Stefan,Sydow-Baeckman, Mona,Thornstroem, Ulla,Uppenberg, Jonas
p. 3565 - 3567
(2007/10/03)
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