486414-51-1Relevant articles and documents
Highly Sensitive Labeling Reagents for Scarce Natural Products
Kuranaga, Takefumi,Minote, Mayuri,Morimoto, Ryota,Pan, Chengqian,Ogawa, Haruka,Kakeya, Hideaki
, p. 2499 - 2506 (2020/10/02)
Scarce natural products that possess unique biological activities have been ideal drug leads for decades. However, their identification and structural determinations are problematic owing to sample amount limitation. Inspired by an extremely rare natural
Bifunctional Phosphonium Salt Directed Enantioselective Formal [4 + 1] Annulation of Hydroxyl-Substituted para-Quinone Methides with α-Halogenated Ketones
Tan, Jian-Ping,Yu, Peiyuan,Wu, Jia-Hong,Chen, Yuan,Pan, Jianke,Jiang, Chunhui,Ren, Xiaoyu,Zhang, Hong-Su,Wang, Tianli
supporting information, p. 7298 - 7302 (2019/10/02)
A highly diastereo- and enantioselective [4 + 1] cycloaddition of para-quinone methides to α-halogenated ketones was realized by bifunctional phosphonium salt catalysis, furnishing functionalized 2,3-dihydrobenzofurans in high yields and excellent stereoselectivities (>20:1 dr and up to >99.9% ee). Mechanistic observations suggested that the reaction underwent a cascade intermolecular substitution/intramolecular 1,6-addition process. DFT calculations revealed the presence of multiple H-bonding interactions between the catalyst and the enolate intermediate in the stereodetermining transition states.
Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids
Shen, Peng-Xiang,Hu, Liang,Shao, Qian,Hong, Kai,Yu, Jin-Quan
supporting information, p. 6545 - 6549 (2018/05/23)
A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.
Total synthesis and complete structural assignment of Yaku'amide A
Kuranaga, Takefumi,Sesoko, Yusuke,Sakata, Komei,Maeda, Naoya,Hayata, Atsushi,Inoue, Masayuki
supporting information, p. 5467 - 5474 (2013/05/22)
Here we report the first total synthesis and the complete stereochemical assignment of yaku'amide A. Yaku'amide A (1) was isolated from a sponge Ceratopsion sp. as an extremely potent cytotoxin. Its structure was determined except for the C4-stereochemist
Novel bifunctional chiral urea and thiourea derivatives as organocatalysts: Enantioselective nitro-Michael reaction of malonates and diketones
Andres, Jose M.,Manzano, Ruben,Pedrosa, Rafae
supporting information; experimental part, p. 5116 - 5119 (2009/05/27)
A modular synthesis of novel bifunctional urea and thiourea organocatalysts derived from cheap, easily accessible natural and non-natural amino acids was reported. The generality of the synthesis was demonstrated in the preparation of catalysts 4a-i in th
Highly active chiral phosphoramide-Zn(II) complexes as conjugate acid-base catalysts for enantioselective organozinc addition to ketones
Hatano, Manabu,Miyamoto, Takashi,Ishihara, Kazuaki
, p. 4535 - 4538 (2008/03/12)
(Chemical Equation Presented) A highly efficient enantioselective organozinc (R2Zn) addition to ketones catalyzed by chiral phosphoramide-Zn(II) complexes (1-10 mol %) has been developed. These complexes serve as conjugate Lewis acid-Lewis base
Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use
-
Page 30-31, (2010/02/03)
Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.