PROCESS FOR SYNTHESIS OF 4-METHYLOXAZOLE-5-CARBOXAMIDE
The present invention provides a novel process for synthesis of 4-methyl-oxazole-5- carboxamide (OXA) which comprises reacting a compound of formula (I) with a high concentration of aqueous ammonia: (I) Wherein R1 is H or C1-10 alkyl.
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(2013/11/18)
PROCESS FOR 4-METHYLOXAZOLE-5-CARBOXAMIDE
A process for the preparation of 4-methyl-oxazole-5-carboxamide, an intermediate in the synthesis of pyridoxine, by reacting lower alkyl 4-methyl-oxazole-5-carboxy-late with a molar excess of anhydrous, liquid ammonia.
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(2013/02/28)
Process for the manufacture of 5-cyano-4-lower alkyl-oxazoles
A process for the manufacture of a 5-cyano-4-lower alkyl-oxazole by the dehydration of a 5-carbamoyl-4-lower alkyl-oxazole is disclosed. The reaction is carried out by dehydrating the oxazole with silicon tetrachloride in the presence of an amine in an aprotic organic solvent. 5-Carbamoyl-4-methyl-oxazole may be dehydrated by the process in accordance with the invention to obtain 5-cyano-4-methyl-oxazole, which is a valuable intermediate in the synthesis of pyridoxine.
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(2008/06/13)
Production of pyridoxine intermediates from diketene
A process for the preparation of oxazoles, particularly 4-lower alkyl-5-cyanooxazoles, from diketene is disclosed.
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(2008/06/13)
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