- Synthesis, Characterization, Molecular Docking, and Antimicrobial Activity of New Arylidene-Substituted Imidazoles
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The title compounds are synthesized by condensation of 2-[4-(arylidene)-5-oxo-4, 5-dihydrooxazol-2-yl]phenylacetate with aromatic amines in presence of the Vilsemeier Haack reagent. Structures of all compounds are elucidated from 1H and 13
- Aparna,Sharada,Subhashini,Sreekanth, Sivan
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p. 1202 - 1208
(2019/07/15)
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- CHEMICAL COMPOUNDS
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A compound which is a pyridine or isoquinoline derivative of formula (I), or a pharmaceutically acceptable salt thereof, which is useful in the inhibition of γ- butyrobetaine hydroxylase (BBOX). The compounds are particularly useful in treatment of cardio
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Page/Page column 29; 30; 32; 33
(2015/07/07)
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- Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases
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Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-α in cells. The Royal Society of Chemistry 2008.
- Lienard, Benoit M.,Conejo-Garcia, Ana,Stolze, Ineke,Loenarz, Christoph,Oldham, Neil J.,Ratcliffe, Peter J.,Schofield, Christopher J.
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supporting information; experimental part
p. 6393 - 6395
(2009/04/13)
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- Effects of mixed CH3CN - H2O solvents on rate of intramolecular general base-catalyzed cleavage of ionized phenyl salicylate in the presence of 3-aminopropan-1 -ol, 1,2-diaminoethane, and glycine
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The effects of mixed CH3CN - H2O solvents on rates of aminolysis of ionized phenyl salicylate, PS-, reveal a nonlinear decrease in the nucleophilic second-order rate constants, knms. (for aminolysis) with increase in the content of CH3CN until it becomes ≈ 50%. v/v. The values of knms remain almost unchanged with change in the CH3CN content within 50 to 70 or 80%, v/v. The effects of mixed CH3CN - H2O solvents on pKa of leaving group, phenol, and protonated amine nucleophile have been concluded to be the major source for the ob- served mixed solvent effects on knms.
- Khan, M. Niyaz
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p. 301 - 307
(2007/10/03)
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- Synthesis of cyclic depsipeptides and peptides via direct amide cyclization
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The 2,2-disubstituted 2H-azirin-3-amines 7 (2,2-disubstituted 3-amino-2H-azirines) were used as amino-acid synthons in the preparation of medium-sized cyclic depsipeptides and peptides derived from salicylic acids 6 and anthranilic acid 19, respectively.
- Villalgordo, Jose M.,Heimgartner, Heinz
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p. 748 - 766
(2007/10/03)
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- Substrate Specificity and Stoichiometry of Nα-Benzyloxycarbonyl Amino Acid Urethane Hydrolase from Streptococcus faecalis R ATCC 8043
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The substrate specificity of a new enzyme, Nα-benzyloxycarbonyl amino acid urethane hydrolase, was investigated.The enzyme hydrolyzed Nα-benzyloxycarbonyl-glycine and -alanine, and Nα-benzoyl-glycine and -alanine.Nα-benzyloxycarbonyl-glycine was hydrolyzed to give equimolar benzyl alcohol and glycine.Equimolar benzoic acid and glycine were produced from Nα-benzoyl-glycine by the enzyme reaction.The Km, k0, and k0/Km values were measured for several substrates.The k0 values varied widely with the amino acid residues.Nα-benzyloxycarbonyl-glycine and Nα-benzoyl-glycine produced relatively small changes in the Km values (0.36 ca. 0.10 mM) and the k0/Km values (99440 ca. 202000 M-1 sec-1).The rate of hydrolysis is significantly affected by electron-supplying substituents on the benzene ring.
- Matsumura, Eiko,Shin, Takashi,Murao, Sawao,Kawano, Tatsu
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p. 973 - 980
(2007/10/02)
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- Esters and amides of salicyloylamino acids
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N Salicyloylamino acids, esters and amides were prepared by the usual condensation methods and also by methods capable of demonstrating 2 (o hydroxyphenyl)oxazoline 5 ones as possible reaction intermediates. Some derivatives showed analgesic and antiinfla
- Mazzotta,Giori,Guarneri,Benassi
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p. 399 - 407
(2007/10/06)
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