- 2-Phenyl-4-hydroxyphthalazin-1-one: A Benzoannelated Derivative of Maleic Hydrazide
-
The monoclinic crystals (space group P21/a, Z = 8) of 2-phenyl-4-hydroxyphthalazin-1-one. C14H10N2O2, have two independent molecules (A and B) in the asymmetric unit. Both occur as the lactim-lactam (hydroxy-one) structure, which is also found in the parent molecule maleic hydrazide (both triclinic and monoclinic polymorphs), dichloromaleic hydrazide and luminol (3-aminophthalhydrazide). The molecular arrangement is based on strings of alternating A and B molecules linked by hydroxyl...carbonyl hydrogen bonds, with only van der Waals interactions between adjacent strings. Comparison is made of the measured bond lengths for (monoclinic) maleic hydrazide and values from high-level ab initio calculations, and reasonably good agreement is obtained, with indications of improvements when allowance is made for electron correlation and hydrogen bonding.
- Becker, Dan,Botoshansky, Mark,Gasper, Noga,Herbstein, Frank H.,Karni, Miriam
-
-
Read Online
- Gram-scale production of nitrogen doped graphene using a 1,3-dipolar organic precursor and its utilisation as a stable, metal free oxygen evolution reaction catalyst
-
For the first time, a one-step scalable synthesis of a few-layer ~10% nitrogen doped (N-doped) graphene nanosheets (GNSs) from a stable but highly reactive 1,3-dipolar organic precursor is reported. The utilization of these N-doped GNSs as metal-free electrocatalysts for the oxygen evolution reaction (OER) is also demonstrated. This process may open the path for the scalable production of other heteroatom doped GNSs by using the broad library of well-known, stable 1,3-dipolar organic compounds.
- Bayazit, Mustafa K.,Moniz, Savio J. A.,Coleman, Karl S.
-
-
Read Online
- INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS
-
This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.
- -
-
Page/Page column 38; 43
(2017/12/18)
-
- A phthalimidation protocol that follows protein defined parameters
-
This work outlines the first phthalimidation protocol suitable for protein labeling and performed in aqueous media at room temperature and neutral pH with no catalyst or co-reagent required. The methodology is suitable for a range of amines and its efficiency was determined with chemoselective and site-selective protein labeling. This journal is
- Singudas, Rohith,Adusumalli, Srinivasa Rao,Joshi, Pralhad Namdev,Rai, Vishal
-
supporting information
p. 473 - 476
(2015/01/09)
-
- A new anhydride analog
-
A novel imide-forming reaction is described in which 3-(dicyanomethylidene) phthalide (pseudoanhydride) reacts with amines at room temperature. The pseudoanhydride was synthesized by condensation of phthalic anhydride with malononitrile followed by treatment with phosphorous oxychloride.
- Moore,Kim
-
p. 3449 - 3452
(2007/10/02)
-