487020-85-9Relevant articles and documents
Biocatalytic one-pot three-component synthesis of 3,3′-disubstituted oxindoles and spirooxindole pyrans using α-amylase from hog pancreas
He, Tao,Zeng, Qing-Qing,Yang, Da-Cheng,He, Yan-Hong,Guan, Zhi
, p. 37843 - 37852 (2015)
α-Amylase from hog pancreas displayed catalytic promiscuity in three-component reaction for the synthesis of 3,3′-disubstituted oxindoles and spirooxindole pyrans. The reactions between isatins, malononitrile and active methyl or active methylene compounds (acetone, nitromethane, indole, acetylacetone, 4-hydroxylcoumarin and dimedone) offered corresponding products via Knoevenagel/Michael reactions or Knoevenagel/Michael/cyclization reactions in one pot with high to excellent yields of up to 98% under mild reaction conditions. The α-amylase showed a broad spectrum of adaptability to various substrates. A possible mechanism of the α-amylase catalyzed three-component reaction was proposed. This journal is
Site-specific role of bifunctional graphitic carbon nitride catalyst for the sustainable synthesis of 3,3-spirocyclic oxindoles in aqueous media
Dandia, Anshu,Mahawar, Dinesh Kumar,Saini, Pratibha,Saini, Surendra,Gupta, Shyam L.,Rathore, Kuldeep S.,Parewa, Vijay
, p. 28452 - 28465 (2021/09/22)
Functionalized graphitic carbon nitride (Sg-C3N4) has been manufactured and used as a reusable catalyst for the one-pot production of various spiro-pyrano chromenes and spiro indole-3,1′-naphthalene tetracyclic systems in aqueous med
γ-Valerolactone as a Promising Bio-Compatible Media for One-Pot Synthesis of Spiro[indoline-3,4'-pyrano[3,2-c]chromene Derivatives
Diwan, Furqan,Farooqui, Mazahar
, p. 2817 - 2822 (2018/10/20)
A general, highly efficient, and green protocol for the synthesis of biologically important spiro[indoline-3,4′-pyrano[3,2-c]chromene derivatives is developed by one-pot, three-component approach involving substituted isatin, active methylene group, and 4
Synthesis of functionalized chromene and spirochromenes using L-proline-melamine as highly efficient and recyclable homogeneous catalyst at room temperature
Nagaraju, Sakkani,Paplal, Banoth,Sathish, Kota,Giri, Santanab,Kashinath, Dhurke
supporting information, p. 4200 - 4204 (2017/10/06)
An efficient and recyclable homogeneous catalyst is developed using commercially cheap L-proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) via multicomponent reactions at room temperature. Systematic studies were conducted in order to achieve desired reactivity and recyclability of the catalyst using various α-amino acids and aromatic amines as donor-acceptor pairs. Among the screened combinations, L-proline and melamine (3:1 ratio; 3 mol% on total weight) was found to be best catalyst to give the desired products with excellent yields (up to 99%) in very short times (1–15 min) at room temperature in DMSO as solvent. The catalyst was recovered by adding EtOAc and reused up to 5 cycles without losing the catalytic activity.
Sulfuric acid-modified poly(ethylene glycol): An efficient, biodegradable, and reusable polymeric catalyst for synthesis of spiro oxindole derivatives in aqueous medium
Nasseri,Zakerinasab
, p. 5261 - 5270 (2015/07/08)
A versatile, novel, and environmentally benign strategy has been successfully developed for synthesis of oxindoles, an important class of potentially bioactive compounds. Sulfonated poly(ethylene glycol) was used as inexpensive and recyclable acidic catal
N-Sulfonic acid modified poly(styrene-co-maleic anhydride): An efficient and recyclable solid acid catalyst for the synthesis of a wide range of spiropyrans
Heravi, Majid M.,Hashemi, Elaheh,Azimian, Fereshteh
, p. 647 - 653 (2015/03/05)
N-Sulfonic acid modified poly(styrene-co-maleic anhydride) as a recyclable solid acid catalyst efficiently catalyzed the one-pot three-component synthesis of spiropyran derivatives through a simple, convenient, and cost-effective approach in good yields a
One-pot, three-component synthesis of spirooxindoles catalyzed by ZnO nano-rods in solvent-free conditions
Hosseini-Sarvari, Mona,Tavakolian, Mina
, p. 826 - 834 (2013/02/25)
Recyclable ZnO nano-rods catalyst as a most efficient and straightforward protocol for one-pot, threecomponent synthesis of spirooxindole derivatives at room temperature under solvent-free conditions in both reaction media and work-up procedure is described. This method is of great value because of its environmentally benign character, easy handling, high yields, convenient operation (grinding), room temperature, low cost and green.
Gold(III) chloride (HAuCl4·3H2O) in PEG: A new and efficient catalytic system for the synthesis of functionalized spirochromenes
Kidwai, Mazaahir,Jahan, Anwar,Mishra, Neeraj Kumar
experimental part, p. 35 - 43 (2012/07/02)
Gold(III) chloride (HAuCl4·3H2O) in PEG 400 was found to be an efficient catalytic system for the synthesis of biologically important functionalized spirochromene derivatives via one-pot three-component reaction of isatins/acenaphthoquinone, active methylene compounds and cyclic 1,3-diketones/4-hydroxycoumarin. A new catalytic system, recyclability of reaction medium, little reaction times and excellent yields with easy workup render this protocol more attractive and economically viable.
Simple and efficient method for three-component synthesis of spirooxindoles in aqueous and solvent-free media
Mobinikhaledi, Akbar,Foroughifar, Naser,Fard, Mohammad Ali Bodaghi
experimental part, p. 441 - 450 (2011/04/15)
A clean, simple, one-pot, three-component synthesis of some important spirooxindole derivatives in the presence of tetrabutylammonium bromide (TBAB) was carried out under green and environmentally benign conditions.
KAl(SO4)212H2O as a recyclable lewis acid catalyst for synthesis of spirooxindoles in aqueous media
Oskooie, Hossein A.,Heravi, Majid M.,Karimi, Narges,Hamidi, Hoda
experimental part, p. 3344 - 3350 (2011/09/19)
A simple and efficient procedure for the synthesis of spirooxindole has been described that employs a three-component condensation reaction in one pot using isatin, active methylene reagent, and 1,3-dicarbonyl compounds in an aqueous medium.