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CAS

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487057-91-0

4-(2,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic acid, also known as Roflumilast, is a complex organic compound that features a pyridine ring and a carboxylic acid group. It functions as a selective phosphodiesterase-4 (PDE4) inhibitor, playing a crucial role in managing inflammation, particularly in respiratory conditions.
Used in Pharmaceutical Industry:
Roflumilast is used as an anti-inflammatory agent for the treatment of severe chronic obstructive pulmonary disease (COPD). It operates by inhibiting the breakdown of cyclic adenosine monophosphate (cAMP), which in turn reduces the production of inflammatory mediators in the respiratory tract, leading to an improvement in lung function and a decrease in inflammation in the airways.

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  • 487057-91-0 Structure

  • Basic information

    1. Product Name: 4-(2,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac
    2. Synonyms: 4-(2,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac;4-(2,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic acid;4-(2,4-Difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid
    3. CAS NO:487057-91-0
    4. Molecular Formula: C13H11F2NO3
    5. Molecular Weight: 267.23
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 487057-91-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(2,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(2,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac(487057-91-0)
    11. EPA Substance Registry System: 4-(2,4-Difluorophenyl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic ac(487057-91-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 487057-91-0(Hazardous Substances Data)

487057-91-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 487057-91-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,7,0,5 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 487057-91:
(8*4)+(7*8)+(6*7)+(5*0)+(4*5)+(3*7)+(2*9)+(1*1)=190
190 % 10 = 0
So 487057-91-0 is a valid CAS Registry Number.

487057-91-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2,4-difluorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyridine-5-carboxylic acid

1.2 Other means of identification

Product number -
Other names 4-(2,4-difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:487057-91-0 SDS

487057-91-0Downstream Products

487057-91-0Relevant articles and documents

NOVEL COMPOUNDS

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Page/Page column 78, (2008/06/13)

Novel inhibitors of Rho-kinases are disclosed.

SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS

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Page column 153; 154, (2010/02/06)

This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therepeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.

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