- Benzoic acid derivatives and related compounds as antiarrhythmic agents
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Benzoic acid derivatives of the formula I where X is oxygen, sulfur, —NH, —NR1, —N—CN, —N—OR1 or —N—NO2; Y is a single bond, —C═C—, or —NH; R1 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclo, or (heterocyclo)alkyl; and R2 is aryl or heterocyclo. The compounds of formula I are useful in the treatment of arrhythmia.
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- Synthesis of All Eight Stereoisomers of the Germination Stimulant Sorgolactone
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The naturally occurring sesquiterpene sorgolactone (2) belongs to the class of "strigolactones", which are highly potent germination stimulants for seeds of the parasitic weeds Striga and Orobanche. The aim of the present work was to synthesize all eight
- Sugimoto, Yukihiro,Wigchert, Suzanne C. M.,Thuring, Jan Willem J. F.,Zwanenburg, Binne
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p. 1259 - 1267
(2007/10/03)
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- The first total synthesis of the naturally occurring germination stimulant sorgolactone
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The first total synthesis of sorgolactone is reported, which confirms the proposed structure of the naturally occurring germination stimulant.
- Sugimoto, Yukihiro,Wigchert, Suzanne C.M.,Thuring, Jan Willem J.F.,Zwanenburg, Binne
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p. 2321 - 2324
(2007/10/03)
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- A new conversion of primary nitro compounds into nitriles
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The reaction of primary nitro compounds with isocyanides and isocyanates in the presence of a base leads to a new preparation of nitriles. The reaction probably proceeds through the in situ formation of a nitrile oxide followed by a fast oxygen transfer with the isocyanide. Combined with the Knovenagel addition of nitromethane to cyclic ketone, this reaction brings a highly effective regioselective formation of cyclic α-β unsaturated nitriles.
- El Kaim, Laurent,Gacon, Ariane
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p. 3391 - 3394
(2007/10/03)
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- One-pot Conversion of Allylic Nitro Compounds Into Nitriles with Carbon Disulphide under Phase-transfer Catalysis Conditions
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An one-pot synthesis of allylic nitriles 3 from the corresponding nitro derivatives 1 is described.In the first step the substrates 1 are reduced to the oximes 2 by carbon disulphide in the presence of wet potassium carbonate, in solid-liquid PTC conditions.In the second, the formed oximes 2 are dehydrated by adding more CS2 and 15percent aqueous NaOH.
- Albanese, Domenico,Landini, Dario,Penso, Michele,Pozzi, Gianluca
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p. 965 - 971
(2007/10/02)
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- Bacteriorhodopsin. The influence of the cyclohexene-ring methyls
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Four ring-demethylated retinals, viz. 1,1',5-tridemethylretinal, 1,1'-didemethylretinal, 1,5-didemethylretinal and 1-demethylretinal, have been synthesized via new and simple schemes.The properties of these modified retinals, their protonated Schiff bases and the corresponding bacteriorhodopsins have been studied and compared with the native system.These bacteriorhodopsin analogues have also been tested for their proton-pump efficiencies.A large decrease in proton-pump activity was found for the analogues lacking the 5-methyl group.On the whole, the opsin shifts of the modified bacteriorhodopsins were much lower than those of the native system.UV-Vis and 1H NMR data support a planar 6-s-trans conformation for the demethylated retinals in solution rather than a twisted 6-s-cis conformation (torsion angle 40-60 deg) as found in retinal.This explains the lower opsin shift and the better fit of these demethylated retinals in bacteriorhodopsin's binding site, which, in its native form, contains a 6-s-trans chromophore.
- Courtin, J. M. L.,Verhagen, L.,Biesheuvel, P. L.,Lugtenburg, J.,Bend, R. L. van der,Dam, K. van
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p. 112 - 119
(2007/10/02)
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- Cyanation of 1-Halocycloalkenes Catalyzed by Tetracyanocobaltate(I). Convenient Synthesis of 1-Cyanocycloalkenes
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1-Cyanocycloalkenes (1-cyanocyclopentene, -hexene, -heptene, and -octene) were readily synthesized by catalytic cyanation of the corresponding 1-halocycloalkenes with tetracyanocobaltate(I).Reactivities of methyl-substituted 1-chlorocyclohexenes were lower than that of 1-chlorocyclohexene, and 1-chloro-2-methylcyclohexene scarecely reacted.Hydrogenation and isomerization of 1-cyanocycloalkenes were observed only with 1-cyanocycloheptene and 1-cyano-6-methylcyclohexene, respectively.
- Funabiki, Takuzo,Kishi, Hirohito,Sato, Yoshihiro,Yoshida, Satohiro
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p. 649 - 650
(2007/10/02)
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