- Quantum Chemical Calculations (Ab Initio & DFT), Hirshfeld Surface Analysis, Crystal Structure and Molecular Docking Study of 2-Chloro-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic Acid Methyl Ester
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Abstract: Pyrimidine derivatives are well-known nitrogen containing heterocyclic compound which play an important role in medicinal and pharmaceutical applications. The synthesized compound, 2-chloro-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic
- Gandhi, Sahaj A.,Patel, Urmila H.,Modh, Rajesh D.,Naliyapara, Yogesh,Patel, Anil S.
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- Facile synthesis of (E)-5-styrylpyrimidines via wittig reaction using sodium tripolyphosphate in water
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An inexpensive and eco-friendly Wittig olefination protocol has been developed to pre-pare novel (E)-5-styrylpyrimidines. The reaction of pyrimidine phosphonium ylide with different aryl/heteroaryl aldehydes underwent smoothly in the presence of sodium tr
- Gandhi, Sahaj A.,Kapuriya, Naval P.,Modh, Rajesh D.,Naliapara, Yogesh T.,Patel, Anilkumar S.,Patel, Urmila H.
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supporting information
p. 634 - 639
(2021/09/30)
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- Efficient Construction of the Nucleus of Rosuvastatin Calcium
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A novel and efficient five-step synthetic route, including a Biginelli reaction, dehydrogenation, chlorination, sulfonamidation, and reduction, for the core of Rosuvastatin was established. All steps were systematically studied. Tert-butylhydroperoxide aqueous solution was applied in the dehydrogenation instead of nitric acid. N,N-dimethylaniline was employed as a catalyst to accelerate the chlorination proceeding smoothly, and its catalytic mechanism is discussed. In the sulfonamidation, the conversion of compound 5 was obviously improved by use of NaH and acetonitrile. In addition, two sulfonamidation side products 6 and 7 were detected and isolated. Thus, under the optimized reaction conditions, the target product was obtained in 60.4% total yield, much higher than the reported yield (36.4%).
- Zhou, Yingtao,Lin, Chenhui,Xing, Yuzhi,Chen, Ligong,Yan, Xilong
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p. 1898 - 1903
(2017/05/29)
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- A PROCESS FOR PREPARING HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES
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The present invention relates to an improved process for synthesizing calcium salt of (E)-7-[4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoic acid (Rosuvastatin Calcium) in high purity.
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Page/Page column 44-45
(2010/01/30)
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