489-18-9

Basic information

• Product Name: 1-(tert-butyl)-2-fluoro-4-nitrobenzene
• Synonyms: 1-(tert-butyl)-2-fluoro-4-nitrobenzene
• CAS NO: 489-18-9
• Molecular Weight: 197.209
• Mol File: 489-18-9.mol

Chemical Properties

• CAS DataBase Reference: 1-(tert-butyl)-2-fluoro-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tert-butyl)-2-fluoro-4-nitrobenzene(489-18-9)
• EPA Substance Registry System: 1-(tert-butyl)-2-fluoro-4-nitrobenzene(489-18-9)

Safety Data

• Hazardous Substances Data: 489-18-9(Hazardous Substances Data)

Usage

Structure

A derivative of benzene with a tert-butyl group at the 1 position, a fluorine atom at the 2 position, and a nitro group at the 4 position.

Applications

a. Organic synthesis
b. Building block in the production of pharmaceuticals and agrochemicals
c. Intermediate in the manufacture of dyes, pigments, and specialty chemicals

Physical state

Pale yellow solid at room temperature

Odor

Slightly fruity

Safety precautions

a. May be harmful if ingested
b. May be harmful if inhaled
c. May be harmful if it comes into contact with the skin

Upstream product

• 103392-84-3 2-tert-Butyl-5-nitro-phenylamine 
• 6310-21-0 2-(1,1-dimethylethyl)-benzenamine 

Downstream Products

• 850040-16-3 1-t-butyl-2-fluoro-4-nitrobenzene 
• 1452184-05-2 4-tert-butyl-3-fluorobenzene-1-sulfonyl chloride 
• 1452182-84-1 4-tert-butyl-3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)benzenesulfonamide 
• 1452182-85-2 N-(1-(2-aminoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide 
• 1452183-67-3 N-(1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide 
• 1452182-88-5 N-(1-(8-aminoquinolin-5-yl)-3-methyl-1H-pyrazol-5-yl)-4-tert-butyl-3-fluorobenzenesulfonamide 
• 1236059-67-8 N-(4-tert-butyl-3-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide 

Relevant articles and documents

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES

Compounds are provided that act as potent antagonists of the CCR(9) receptor for treating Sjogren's syndrome. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions.

AMIDE COMPOUND

The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

Heterocyclic compound

The present invention relates to compound (I) or a salt thereof which has a ROR γ t inhibitory action. wherein each symbol is as defined in the specification.

Discovery of N -(2,4-Di- tert -butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a potent and orally bioavailable CFTR potentiator

Quinolinone-3-carboxamide 1, a novel CFTR potentiator, was discovered using high-throughput screening in NIH-3T3 cells expressing the F508del-CFTR mutation. Extensive medicinal chemistry and iterative structure-activity relationship (SAR) studies to evaluate potency, selectivity, and pharmacokinetic properties resulted in the identification of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, 48, ivacaftor), an investigational drug candidate approved by the FDA for the treatment of CF patients 6 years of age and older carrying the G551D mutation.

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES

Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators.