Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists
Structure-activity relationship studies directed toward the optimization of 4,5-diarylimidazole-2-carboxamide analogs as human CB1 receptor inverse agonists resulted in the discovery of the two amide derivatives 24a and b (hCB1 IC50 = 6.1 and 4
Plummer, Christopher W.,Finke, Paul E.,Mills, Sander G.,Wang, Junying,Tong, Xinchun,Doss, George A.,Fong, Tung M.,Lao, Julie Z.,Schaeffer, Marie-Therese,Chen, Jing,Shen, Chun-Pyn,Stribling, D. Sloan,Shearman, Lauren P.,Strack, Alison M.,Van Der Ploeg, Lex H.T.
p. 1441 - 1446
(2007/10/03)
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