- Transition-Metal-Free Valorization of Biomass-derived Levulinic Acid Derivatives: Synthesis of Curcumene and Xanthorrhizol
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Levulinic acid (LA) is acknowledged one of the most promising biomass-derived platform molecules and can be transformed into various value-added chemicals. Here, we report a new reaction process for the valorization of LA derivatives under transition-meta
- Fu, Yao,Gong, Tian-Jun,Xu, Wen-Yan,Zhuo, Kai-Feng
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p. 884 - 891
(2020/12/13)
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- Method for synthesizing alkyne through catalytic asymmetric cross coupling (by machine translation)
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The invention belongs to the field of, asymmetric synthesis, and discloses a method for catalyzing asymmetric cross- coupling to synthesize: an alkyne, and the L method comprises, the following steps, of A: preparing B a cuprous, salt and C a: ligand; preparing a catalyst; adding a base; reacting the compound with the compound with the compound; and reacting the compound with the compound. Of these, one of them, X is selected from the group consisting of, R halogens. 1 Optionally substituted heteroarylsulfonylcyanamide groups selected from the, group consisting, of optionally substituted, phenyl groups In-flight vehicle, R6 Trialkyl silyl groups or alkyl radicals, R2 Cycloalkyl radicals optionally substituted with an, optionally substituted alkyl, (CH radical2 )n R4 Multi,layer chain, n=0-10,R saw blade4 A group selected, from, the group consisting of phenyl, alkenyl, aralkynyls, noonyloxy,and, noonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylphenyl disiloxy-radicals. R3 A ligand, selected from hydrogen or any of the functional groups, is selected from the group consisting of, hydrogen and any L other functional group. The method, R disclosed by the, A invention has the, advantages of good catalytic, R ’ effect, wide application range. and high catalytic efficiency, and the, method disclosed by the, invention has the. advantages of good catalytic effect, wide application range and high catalytic efficiency. (by machine translation)
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Paragraph 1062; 1074-1076
(2020/01/12)
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- A asymmetric catalytic synthesis (S)- aryl curcumene method
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The invention discloses a method for asymmetrically catalyzing and synthesizing (S)-curcumene. According to the method, racemization 2-halogenated propionate ester serves as a starting material, under the catalysis of bis oxazoline/ cobalt, an asymmetrica
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Paragraph 0011; 0042
(2017/08/25)
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- Asymmetric synthesis of (R)-ar-curcumene, (R)-4,7-dimethyl-l-tetralone, and their enantiomers via cobalt-catalyzed asymmetric Kumada cross-coupling
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An efficient and concise asymmetric synthesis of (R)-(+)-ar-curcumene, (R)-4,7-dimethyl-l-tetralone, and their enantiomers was accomplished. The key step to construct the stereogenic benzylmethyl centers of these natural products is the cobalt-catalyzed a
- Wu, Lin,Zhong, Jiang-Chun,Liu, Shi-Kuo,Liu, Fei-Peng,Gao, Zi-Dong,Wang, Min,Bian, Qing-Hua
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- Enantioselective copper-catalyzed conjugate addition of trimethylaluminum to β,γ-unsaturated α-ketoamides: Efficient access to γ-methyl-substituted carbonyl compounds
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Picture perfect: By using the reagent trimethylaluminium and β,γ-unsaturated α-ketoamides, 1,4-adducts were obtained with perfect 1,4-regioselectivity and good to excellent yields and ee values. The potential synthetic utility of the methodology was highl
- Goncalves-Contal, Sylvie,Gremaud, Ludovic,Alexakis, Alexandre
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p. 12701 - 12704
(2013/12/04)
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- Protecting group free formal total synthesis of the antitubercular agent erogorgiaene
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The formal total synthesis of the antitubercular agent erogorgiaene was achieved in 12 steps by using a protecting group free strategy. The synthesis involves an enamine-mediated 1,4-addition, an aldol condensation, dehydrogenation, Wittig olefination, in
- Yadav, Jhillu S.,Thirupathaiah, Bodakuntla,Al Khazim Al Ghamdi, Ahmad
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p. 2072 - 2076
(2012/05/05)
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- trans-directing ability of the amide group: Enabling the enantiocontrol in the synthesis of 1,1-dicarboxy cyclopropanes. Reaction development, scope, and synthetic applications
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(Chemical Equation Presented) In this article, we describe our efforts toward the enantioselective formation of 1,1-cyclopropane diesters via the metal-catalyzed cyclopropanation of olefins. The strategies envisioned to achieve such a goal are discussed a
- Marcoux, David,Goudreau, Sebastien R.,Charette, Andre B.
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supporting information; experimental part
p. 8939 - 8955
(2010/03/02)
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- An aldol approach to the synthesis of the anti-tubercular agent erogorgiaene
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A total synthesis of erogorgiaene is described in 16 steps. The synthesis relies upon a highly diastereoselective intramolecular Friedel-Crafts reaction of an oxetane derived via an asymmetric syn aldol coupling.
- Yadav,Basak,Srihari
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p. 2841 - 2843
(2007/10/03)
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- Enantioselective synthesis of (+)-nuciferal, (+)-(E)-nuciferol and (+)-α-curcumene by chiral hydrogenesterification reaction
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Using chiral hydrogenesterification reaction as the key step, the stereoselective synthesis of (+)-nuciferal 1, (+)-(E)-nuciferol 2 and (+)-a-curcumene 3 has been achieved.
- Du, Zhenfing,Yue, Guoren,Ma, Junying,She, Xuegong,Wu, Tongxing,Pan, Xinfu
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p. 427 - 429
(2007/10/03)
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- Synthesis of aryl-substituted aldehydes and ketones via palladium-catalyzed coupling of aryl halides and non-allylic unsaturated alcohols
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The palladium-catalyzed coupling of aryl halides and non-allylic unsaturated alcohols affords excellent yields of aryl-substituted aldehydes and ketones.
- Larock,Leung,Stolz-Dunn
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p. 6629 - 6632
(2007/10/02)
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- Enantiodivergent Route to the Aromatic Bisabolane Sesquiterpenes by Regio- and Stereo-controlled Epoxide Opening
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An enantiodivergent route to aromatic bisabolane sesquiterpenes from a single chiral precursor has been established by employing regio- and stereo-controlled epoxide opening as the key step.
- Takano, Seiichi,Yanase, Masashi,Sugihara, Takumichi,Ogasawara, Kunio
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p. 1538 - 1540
(2007/10/02)
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- THE FIRST STEREOSELECTIVE SYNTHESIS OF (+)-NUCIFEROL AND (+)-NUCIFERAL
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Using (S)-benzyl 2,3-epoxypropyl ether (1), the first stereoselective synthesis of (+)-nuciferol (14) and (+)-nuciferal (16) has been achieved.Employing the same methodology an enantioselective synthesis of (+)-α-curcumene (17) is also described.
- Takano, Seiichi,Goto, Emiko,Ogasawara, Kunio
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p. 5567 - 5570
(2007/10/02)
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