- Convenient synthesis of imidazo[1,5-a]pyrimidine derivatives and their unusual recyclization into 3H-imidazo[4,5-b]pyridine derivatives
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[Figure not available: see fulltext.] New derivatives of imidazo[1,5-a]pyrimidine have been synthesized by cyclization of in situ generated 1H-imidazol-4(5)-amine with 1,3-diketones or malondialdehyde derivatives. Utilization of asymmetrical 1,3-diketones leads to the formation of a mixture of regioisomers. The discovered conversion of imidazo[1,5-a]pyrimidine core into 3H-imidazo[4,5-b]pyridine that takes place only under acidic conditions can be considered as a new version of Dimroth rearrangement involving cleavage of C–N bond and formation of C–C bond.
- Smirnova, Olga V.,Tolkunov, Andrew S.,Tolkunov, Sergei V.,Tolkunov, Valery S.
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p. 554 - 559
(2021/06/14)
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- INDAZOLES AS LRRK2 INHIBITORS
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The present invention is directed to indazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.
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Page/Page column 190
(2020/10/09)
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- Determination of inter-ionic and intra-ionic interactions in a monofluorinated imidazolium ionic liquid by a combination of X-ray crystallography and NOE NMR spectroscopy
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We report the very first application of a Transient 1D 1H{19F} NOE NMR experiment in neat ionic liquids. In comparison with classical 2D HOESY NMR spectroscopy, a substantial reduction in measurement time is gained with comparable quality and information content of the spectra. In combination with classical X-ray crystallography, we have applied this technique for the determination of inter-ionic distances (i.e. probabilities of presence) utilizing an ionic liquid containing a monofluorinated imidazolium cation. Copyright
- Lingscheid, Yves,Paul, Mathias,Br?hl, Andreas,Neud?rfl, J?rg-Martin,Giernoth, Ralf
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- Trinuclear {Co2+-M3+-Co2+} complexes catalyze reduction of nitro compounds
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This work presents synthesis and characterization of trinuclear {Co2+-Co3+-Co2+} and {Co2+-Fe3+-Co2+} complexes with accessible peripheral Co(ii) ions. Both trinuclear complexes function as efficient reusable heterogeneous catalysts for the selective reduction of assorted nitro compounds to the corresponding amines. The mechanistic investigations suggest the involvement of a Co(ii)-Co(i) cycle in the catalysis.
- Srivastava, Sumit,Dagur, Manvender S.,Ali, Afsar,Gupta, Rajeev
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p. 17453 - 17461
(2015/10/19)
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- Mannich-type C-nucleosidations in the 5,8-diaza-7,9-dicarba-purine family
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(Chemical Equation Presented) C-Nucleosidation with cyclic iminium salts occurring under mild reaction conditions and affording C-nucleosides that are isosteric with N-nucleosides of natural purines is shown to be a consistent property of the entire family of 2,6-(oxo or amino)-disubstituted 5,8-diaza-7,9-dicarba-purines.
- Han, Bo,Jaun, Bernhard,Krishnamurthy, Ramanarayanan,Eschenmoser, Albert
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p. 3691 - 3694
(2007/10/03)
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- Preparation, Structure and Addition Reactions of 4- and 5-Aminoimidazoles
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Catalytic reduction of 5-nitroimidazoles 4 in dioxane solution gives 5-aminoimidazoles 2 in good yield.The derivatives 2d-f were isolated as stable, crystalline compounds which undergo slow decomposition on exposure to air.In a similar manner, solutions o
- Al-Shaar, Adnan H. M.,Gilmour, David W.,Lythgoe, David J.,McClenaghan, Ian,Ramsden, Christopher A.
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p. 2779 - 2788
(2007/10/02)
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- Purines, Pyrimidines, and Imidazoles. Part 54. Interconversion of Some Intermediates in the de novo Biosynthesis of Purine Nucleotides
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Ethyl and benzyl 5-amino-1-(2-pyridyl)imidazole-4-carboxylates, obtained from ethyl or benzyl α-amino-α-cyanoacetate, respectively, and ethyl formimidate hydrochloride followed by 2-aminopyridine, were converted into 5-amino-1-(2-pyridyl)imidazole-4-carboxylic acid which was decarboxylated in situ to 5-amino-1-(2-pyridyl)imidazole.Reaction of 2-N-formylamino-N-(2-pyridyl)acetamide with ammonia and ammonium chloride gave 5-aminoimidazole and a similar reaction with the nucleotide 2-N-formylglicineamide ribotide similarly gave evidence for aminoimidazole formation. 4-Cyano-5- imidazolone, prepared by reaction of 2-cyano-N-formylacetamide with nitrous acid and reduction of the hydroxyimino derivative so produced, with ammonia and ammonium sulphite at 100 deg C, gave 5-aminoimidazole-4-carboxamide.Implications of the reactions involved are discussed.
- Cusack, Noel J.,Shaw, Gordon,Logemann, Fatma I.
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p. 2316 - 2321
(2007/10/02)
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