492431-12-6

Basic information

• Product Name: 1-Boc-4-(Pyridazin-3-yl)piperazine
• Synonyms: 1-Boc-4-(Pyridazin-3-yl)piperazine;tert-butyl 4-pyridazin-3-ylpiperazine-1-carboxylate
• CAS NO: 492431-12-6
• Molecular Formula: C13H20N4O2
• Molecular Weight: 264.3235
• Mol File: 492431-12-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Boc-4-(Pyridazin-3-yl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-(Pyridazin-3-yl)piperazine(492431-12-6)
• EPA Substance Registry System: 1-Boc-4-(Pyridazin-3-yl)piperazine(492431-12-6)

Safety Data

• Hazardous Substances Data: 492431-12-6(Hazardous Substances Data)

Usage

Chemical class

Piperazine derivative

Functional groups

Boc (tert-butoxycarbonyl) protecting group, pyridazinyl ring

Application

Intermediate in the synthesis of pharmaceuticals and bioactive molecules

Utilization

Development of potential drug candidates for various diseases and conditions

Boc protecting group

Protects and manipulates amine functional groups in organic synthesis

Pyridazinyl ring

Confers specific pharmacological properties to resulting molecules

Importance

Significant role in medicinal chemistry and pharmaceutical research

Upstream product

• 492431-11-5 4-(6-chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1120-95-2 3-chloropyridazine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 51047-56-4 1-(3'-pyridazinyl)piperazine 

Relevant articles and documents

PHENYL mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group —OR5; a group —CH2OR5; a group —NR6R7; a group —NR8COR9; a group —NR8CONR10R11; a group —CH2NR12R13; a group —CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group —CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin V1b receptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the V1a receptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.