494854-19-2

Basic information

• Product Name: ethyl 2-(4-(tert-butoxycarbonylamino)phenyl)thiazole-4-carboxylate
• Synonyms: ethyl 2-(4-(tert-butoxycarbonylamino)phenyl)thiazole-4-carboxylate;ethyl 2-(4-(tert-butoxycarbonylaMino)phenyl)thiazole-4-carboxyla;Ethyl2-[4-(Boc-amino)phenyl]thiazole-4-carboxylate
• CAS NO: 494854-19-2
• Molecular Formula: C₁₇H₂₀N₂O₄S
• Molecular Weight: 348.4167
• Mol File: 494854-19-2.mol

Chemical Properties

• Appearance: /
• Density: 1.240±0.06 g/cm3(Predicted)
• PKA: 13.25±0.70(Predicted)
• CAS DataBase Reference: ethyl 2-(4-(tert-butoxycarbonylamino)phenyl)thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-(tert-butoxycarbonylamino)phenyl)thiazole-4-carboxylate(494854-19-2)
• EPA Substance Registry System: ethyl 2-(4-(tert-butoxycarbonylamino)phenyl)thiazole-4-carboxylate(494854-19-2)

Safety Data

• Hazardous Substances Data: 494854-19-2(Hazardous Substances Data)

Upstream product

• 730234-73-8 ethyl 2-(4-aminophenyl)thiazole-4-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100367-77-9 ethyl 2-bromothiazole-4-carboxylate 

Downstream Products

• 400776-12-7 2-(4-tert-butyloxycarbonylaminophenyl)thiazole-4-carboxylic acid 
• 494854-18-1 4-(4-ethoxycarbonyl-thiazol-2-yl)-phenyl-ammonium chloride 

Relevant articles and documents

AMINO ACIDS

Compounds of formula (I): Z’ -CO-A-B-NH-Z (I) wherein: Z is H or an amino protecting group; Z’ is OH, a protected or activated hydroxyl group or C1; A is an optionally substituted C5-6 arylene group; and B is an optionally substituted C5-6 arylene group.

Viral polymerase inhibitors

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I: wherein R1 is selected from: H, haloalkyl, (C1-6)alkyl, (C2-6)alkenyl, (C3-7)cycloalkyl, (C2-6)alkynyl, (C5-7)cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted; R2 is selected from (C1-6)alkyl, (C3-7)cycloalkyl, (C6-10)bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted; B is N or CR5, wherein R5 is H, halogen, haloalkyl, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; X is N or CR5; D is N or CR5; each of Y1 and Y2 is independently O or S; Z is O, N, or NRz wherein Rz is H, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; R3 and R4 are each independently H, (C1-6)alkyl, first (C3-7)cycloalkyl or 6- or 10-membered aryl, Het (C1-6)alkyl-6- or 10-membered aryl, (C1-6)alkyl-Het; or each R3 and R4 are independently covalently bonded together to form second (C3-7)cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R3 or R4 are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R7 is H, (C1-6 alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; or R7 is covalently bonded to either of R3 or R4 to form a heterocycle; A is (C1-6) alkyl-CONHR8 wherein R8 is-6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B polymerase.